Avoid These Risk Factors to Prevent Brain Inflammation with Dr. Datis Kharrazian



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For a long time, brain fatigue and a lack of cognitive endurance were just considered a normal part of aging. These issues are actually symptoms of a much larger problem, though—neuroinflammation—and they aren’t inevitable. 

Our brains naturally create cellular debris as we age. A healthy brain with the right anti-inflammatory and antioxidant systems in place can clean up this debris using a process called autophagy. But when those systems become compromised through a variety of insults, like insulin resistance, toxicity, and lack of sleep, the debris piles up and neurodegeneration and inflammation result. Taking the right steps now can prevent and even reverse an inflamed brain. 

On today’s episode, Dhru talks to Dr. Datis Kharrazian about the principles of health that protect and optimize our brain function. 

Dr. Kharrazian is a clinical research scientist, academic professor, and a Functional Medicine health care provider. He is an Associate Clinical Professor at Loma Linda University School of Medicine, a Research Fellow at Harvard Medical School, and a researcher at the Department of Neurology at Massachusetts General Hospital.  

Dr. Kharrazian earned a PhD degree in Health Science with concentrations in immunology and toxicology and a Doctor of Health Science degree from Nova Southeastern University. He completed his post-doctoral research training at Harvard Medical School and Massachusetts General Hospital. Dr. Kharrazian earned a Master of Science degree in Human Nutrition from the University of Bridgeport, a Doctor of Chiropractic degree from Southern California University of Health Sciences, and a Master of Medical Sciences degree in Clinical Investigation from Harvard Medical School.

In this episode, we dive into: 

  • The link between diabetes and Alzheimer’s (6:58) 
  • What is neuroinflammation and what causes it (11:29) 
  • The earliest signs of neuroinflammation (14:10) 
  • Conditions that are tied to neuroinflammation (16:56) 
  • The impact of air pollution on our brain (19:32) 
  • Dr. Kharrazian’s recommendations to maintain healthier indoor air quality (23:12) 
  • How poor sleep can drive neuroinflammation (33:08) 
  • What role glial cells—the brain’s immune cells—play in neuroinflammation, and what it means when they are primed (48:52) 
  • Why gluten is one of the most inflammatory foods for the brain (59:52) 
  • Molecular mimicry and how it can drive autoimmunity (1:10:14)

Also mentioned in this episode:

For more on Dr. Kharrazian you can follow him on Instagram @datiskharrazian, on Facebook @datiskharrazianpage, on YouTube @datiskharrazian, and through his website drknews.com/

For more on Dhru Purohit, be sure to follow him on Instagram @dhrupurohit, on Facebook @dhruxpurohit, on Twitter @dhrupurohit, and on YouTube @dhrupurohit. You can also text Dhru at (302) 200-5643 or click here.

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Wishing you health and happiness,
Mark Hyman, MD
Mark Hyman, MD


Mark Hyman, MD

Mark Hyman, MD is the Founder and Director of The UltraWellness Center, the Head of Strategy and Innovation of Cleveland Clinic's Center for Functional Medicine, and a 13-time New York Times Bestselling author.

If you are looking for personalized medical support, we highly recommend contacting Dr. Hyman’s UltraWellness Center in Lenox, Massachusetts today.


If you are looking for personalized medical support, we highly recommend contacting Dr. Hyman’s UltraWellness Center in Lenox, Massachusetts today.

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