How Leaky Gut is Making Us Sick and Driving Chronic Inflammation with Dr. Emeran Mayer



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Over the last seventy-five years, an array of serious, seemingly unrelated chronic illnesses—cardiovascular disease, diabetes, metabolic syndrome, autoimmune disorders, cancer, and brain disorders—have all been steadily rising, some at astonishing rates. While we’re living dramatically longer lives, many of us are suffering throughout them, creating a public health crisis of historic scale.

A key principle of Functional Medicine is looking at the gut and how it impacts the entire body. All of the diseases mentioned above have a component of gut dysfunction, especially intestinal permeability, which is also known as leaky gut syndrome. When the digestive tract is inflamed and food particles are able to make their way into the bloodstream, the body goes into fight mode. This goes far beyond a stomach ache, as symptoms can occur throughout the whole body.

On today’s episode of The Dhru Purohit Podcast, Dhru sits down with Dr. Emeran Mayer, the author of The Gut-Immune Connection and The Mind-Gut Connection. He has studied brain-body interactions for the last forty years and is the executive director of the G. Oppenheimer Center for Neurobiology of Stress and Resilience, and the founding director of the UCLA Brain Gut Microbiome Center at the University of California at Los Angeles. His research has been supported by the National Institutes of Health for the past twenty-five years, and he is considered a pioneer and world leader in the area of brain-gut microbiome interactions and its clinical implications.

In this episode, we dive into: 

  • Industrial agriculture, antibiotics, and the implications on human health (5:35)
  • The connection between the overuse of antibiotics and weight gain (12:17)
  • How our gut bacteria evolved (17:02)
  • The intelligence of our gut bacteria (27:03)
  • How modern pesticides wreak havoc on our gut health (33:46)
  • How fermented foods increase microbiome diversity and lower inflammation (39:26) 
  • The importance of diversity in our diet (51:19)
  • Why there is a prevalence of food sensitivity in our diet (53:12)
  • How to figure out what foods are negatively impacting your gut health (1:03:09)
  • How sleep impacts the gut microbiome (1:13:12)
  • The gut-immune connection (1:19:15)
  • Chronic disease epidemic and the susceptibility to infectious diseases like COVID-19 (1:24:40)

Also mentioned in this episode:

For more on Dr. Mayer you can follow him on Instagram @emeranmayer, on Facebook @emeranamayer, on Twitter @emeranamayer, and through his website Get his book, The Gut-Immune Connection: How Understanding the Connection Between Food and Immunity Can Help Us Regain Our Health here.

For more on Dhru Purohit, be sure to follow him on Instagram @dhrupurohit, on Facebook @dhruxpurohit, on Twitter @dhrupurohit, and on YouTube @dhrupurohit. You can also text Dhru at (302) 200-5643 or click here.

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Wishing you health and happiness,
Mark Hyman, MD
Mark Hyman, MD


Mark Hyman, MD

Mark Hyman, MD is the Founder and Director of The UltraWellness Center, the Head of Strategy and Innovation of Cleveland Clinic's Center for Functional Medicine, and a 13-time New York Times Bestselling author.

If you are looking for personalized medical support, we highly recommend contacting Dr. Hyman’s UltraWellness Center in Lenox, Massachusetts today.


If you are looking for personalized medical support, we highly recommend contacting Dr. Hyman’s UltraWellness Center in Lenox, Massachusetts today.

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