Flax Flash!


LOOKING TO COOL DOWN those blistering hot flashes naturally? You may want to sprinkle some ground flaxseed on your cereal, toss some in your smoothie or grab a flaxseed muffin. Just a little over 1 ounce/day may tame those troubling transient temperature rises. The best news yet, Flaxseeds have a wonderful, nutty taste. In fact, Dr. Hyman has several delicious recipes in his book UltraMetabolism that includes them as a healthy, nutritious ingredient.

A hot flash is often described as a flush of intense warmth across much of the body that may be accompanied by sweating, reddening of the skin, or, occasionally, cold shivers. Hot flashes occur in varying frequency and duration, even during sleep, and often cause or accompany sleep deprivation, anxiety and irritability.

“Hot flashes are a bothersome issue for women experiencing menopause,” says Sandhya Pruthi, M.D.,  the Mayo Clinic breast health specialist and the study’s primary investigator. “We hope to find more effective nonhormonal options to assist women, and flaxseed looks promising.”

Although until recently hormone replacement therapy was the most commonly prescribed treatment for hot flashes, unwanted side effects have led to the search for nonhormonal solutions. Several effective nonhormonal drug therapies have been identified, but they are not always effective, and not all women can use them because of side effects. These limitations have led researchers to explore non-drug agents. They have studied a variety of herbal and dietary supplements in randomized, placebo-controlled trials, including vitamin E, black cohosh and soy, but none has shown to produce any significant reduction in frequency or severity of hot flashes.

The 29 participants in Mayo’s clinical trial were women with bothersome hot flashes who did not want to take estrogen because of a perceived increased risk of breast cancer. They also had not received (in the preceding four weeks) antineoplastic chemotherapy, androgens, hormonal agents, or other herbal supplements, including soy. Some patients did not complete the trial, but full data for six weeks of flaxseed therapy, consisting of 40 grams of crushed flaxseed ingested daily, was obtained from 21 of them.

Participants were asked questions that the researchers translated into a hot flash score — a combined measure of frequency and severity. The frequency of hot flashes decreased 50 percent over six weeks, and the overall hot flash score decreased an average 57 percent for the women who completed the trial. Participants also reported improvements in mood, joint or muscle pain, chills and sweating; which significantly improved their health-related quality of life.

“We are quite pleased with the improvements noted by these women in their quality of life,” says Dr. Pruthi. “Not only does flaxseed seem to alleviate hot flashes, but it appears to have overall health and psychological benefits as well.”

Dr. Pruthi’s team chose to research flaxseed because it is a phytoestrogen (plant-based estrogen source). Flaxseed contains lignans and omega-3 fatty acids. Lignans are antioxidants with weak estrogen-emulating characteristics, and have some anti-cancer effects. Flaxseed also appears to have anti-estrogen properties and has been shown in some recent research trials to decrease breast cancer risk. The researchers hypothesized that patients taking flaxseed might gain some relief for hot flashes.

This pilot trial was designed to determine the effectiveness of flaxseed in alleviating hot flashes and identify possible side effects. Dr. Pruthi cautions that the results are preliminary and taking flaxseed may not give relief to every woman suffering hot flashes.

“While results were promising, we have more research to conduct,” she says. “Oftentimes, pilot studies show promising results that upon further study in a large, randomized placebo-controlled study turn out to be much less remarkable.”

Dr. Pruthi’s research team hopes to open a new, larger clinical trial evaluating flaxseed against a placebo to better refine the results, and to hopefully confirm flaxseed as a new treatment option for hot flashes in women.

Other Mayo Clinic researchers included Charles Loprinzi, M.D.; Susan Thompson; Paul Novotny; Debra Barton, Ph.D.; Lisa Kottschade; Angelina Tan; and Jeff Sloan, Ph.D. The flaxseed study was supported in part by the Susan G. Komen Breast Cancer Foundation.

More information on clinical trials is available at Mayo Clinic.

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5 Responses to Flax Flash!

  1. Marilyn Connor August 8, 2010 at 11:50 am #

    Since this article says “Dr. Pruthi’s research team hopes to open a new, larger clinical trial in 2008”, is there an update on this research? I have had severe hot flashes (full-on sweating 1-3 times per hour, except at nights: 1-3 sessions total) for >5 years, and I lost all patience with it lately and started HRT (Estrace and Prometrium, which I understand are fairly ‘natural’ when it comes to HRT). Nevertheless, I don’t want to stay on this, due to the risks. So it would help to know that Flaxseed helps. I will now add it to my daily diet, but still want to know the research. Thanks.

  2. Darlene January 14, 2012 at 6:40 am #

    I eat flaxseed (organic crushed) on my cereal every day. IT WORKS! So much so, that being winter time, I’m thinking about backing off it some so my internal thermostat will warm me up again! I would recommend this to all women. It is food, no side effects, nothing to lose by trying it. I am anti drug and pro supplements.

  3. Sandra January 14, 2012 at 11:35 pm #

    I too would love to know what research has been done since 2008. I have used two tbsp. of ground flaxseed in my daily protein shake for the past 4 years. I am smack dab in the perimenopause / menopause stage (age 54) & have had lots of hotflashes, but nothing serious or life altering; they have little impact on my life because they are not very severe.

  4. Sally January 15, 2012 at 4:05 am #

    is this stuff(ground flaxsreed safe to take if i am also on warfarin?A

    • Profile photo of Mark Hyman, MD
      Mark Hyman, MD January 16, 2012 at 7:36 pm #

      Hi Sally,

      Thank you for inquiry about flaxseed and warfarin. research shows that there is the potential for flax seed to increase warfarin and any substance that increases blood thinning. You might interpret this as eating in moderation…

      In good health!

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