Is Alzheimer’s Reversible? Getting to the Root Causes

Episode 167 1h 12m


Alzheimer’s doesn’t just happen overnight; it’s the severe end of a spectrum, that comes after decades of changes have already been occurring in the brain. So why is it that we’ve grown accustomed to dreading this diagnosis, instead of doing what we can to proactively stop it in its tracks? For one, we’ve long been told that once the brain starts downsizing we can’t reverse the process. Now, we know that’s not the case. It’s possible to avoid brain degradation and actually even rebuild it.

Today’s guest on The Doctor’s Farmacy has been a pioneering detective for Alzheimer’s and other neurological issues. Dr. Dale Bredesen and I talk about the many factors that lead to inflammation in the brain, cognitive decline, and eventually Alzheimer’s. Exposure to toxins like mercury and mold, nutrient deficiencies, hormonal imbalances, and an overload of sugar are some of the most common contributors.

Genetics play a part, too—Dr. Bredesen breaks down the different ways the ApoE4 gene increases Alzheimer’s risk and how it impacts the general population. We also talk about the relationship between insulin resistance and the spectrum of brain disorders and why limiting sugar is such an essential piece when treating the brain. Cognitive decline stems from an insufficiency in the network that mediates plasticity—the ability to change and mold the brain, to add new thoughts and memories. Insults, like sugar, damage our synapses and stop information from being transmitted effectively, taking us from plasticity to rigidity. When we look at those insults we begin getting to the root cause of brain damage. We talk about all this and more on this episode.

I hope you’ll tune in to hear about the groundbreaking program for preventing and treating Alzheimer’s that Dr. Bredesen has created.


This episode is brought to you by BiOptimizers, Thrive Market, and TrueDark. The Doctor’s Farmacy podcast works with a select group of sponsors to allow for ongoing production and allow it to be zero-cost to anyone who wishes to listen to and watch the podcast.

Topics Covered

  • Addressing the root causes of dementia, cognitive decline, and Alzheimer's disease

    (3:49 - 8:02)

  • How a ketogenic diet and metabolic flexibility can support brain function

    (7:39 - 11:52)

  • The way your brain responds to inflammation, and how inflammation drives cognitive decline and Alzehimer’s disease

    (11:33 - 15:46)

  • What is a cognoscopy and how can you get one?

    (21:48 - 26:01)

  • Your brain can grow and improve, even after an Alzheimer’s diagnosis

    (26:28 - 31:10)

  • The gut-brain connection

    (28:36 - 33:18)

  • Heavy metals and their effects on the brain

    (31:49 - 36:31)

  • Hormonal dysfunction and risk of Alzheimer’s disease

    (36:46 - 41:28)

  • How nutrient deficiencies drive cognitive decline and the diet that is best for your brain

    (40:19 - 45:01)

  • Is it possible to reverse Alzheimer’s disease, and if so, to what degree?

    (53:48 - 58:30)

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Ep. 167 - Is Alzheimer’s Reversible? Getting to the Root Causes