The Secrets Of Activating Your Longevity Switches

Episode 571 1h 27m
Topics Overview


What’s the point in living a long time? Being fully in contribution to life. I want to do that feeling healthy and vital, not sick and decrepit. Everything we do speaks to our genes—the food we eat, our relationships, our environment. You’re either telling your genes to age faster or age slower. So I’m constantly working on how to give my genes the right information to do the latter. Today’s podcast episode was recorded on my recent trip to Antarctica with my own doctor, Dr. Matt Cook. He’s helped me heal and has integrated so many different forms of technologies and science to rebuild people’s health from the ground up. Throughout this episode, we explore some of the most profound breakthroughs in understanding human biology and how to reduce the symptoms of aging. The nutritional part is multidimensional—it’s about getting the right nutrients in, getting the toxic ingredients out, and then reaping the benefits of other components like fiber, probiotics, and phytochemicals. Supplements can be a helpful complement to a wholesome diet, which Dr. Cook and I elaborate on as well. We explain the concepts of oxidative stress, inflammation, mitochondria, mTOR, and so much more. All of us have longevity switches built into our bodies, we just have to use the right inputs to turn them on. Dr. Cook joins me in breaking down these areas of longevity and we talk about the regenerative medicine therapies and protocols that we’ve both had success with. Things like stem cells, exosomes, nutrient IVs, hyperbaric oxygen, and beyond. Hormetic stressors cause just enough stress on the body to elicit healing actions without causing harm. Dr. Cook and I discuss how we can use therapies like these, which include cold therapy, ozone, and others, to maximize healing and reverse aging. It’s amazing what we can do to feel better at any age. Whether you want to do things from home like making diet or lifestyle changes or jump into more advanced therapies with a regenerative medicine doctor, this is a great episode to learn from and create your own healthy-aging plan. BiOptimizers Magnesium Breakthrough formula contains seven different forms of magnesium, all of which have different functions in the body. There is truly nothing like it on the market. Go to and use code hyman10 at checkout for 10% off your next order. Rupa Health is a place where Functional Medicine practitioners can access more than 2,000 specialty lab tests from over 20 labs like DUTCH, Vibrant America, Genova, and Great Plains. You can check out a free, live demo with a Q&A or create an account at Pendulum is the first company to figure out how to harness the amazing benefits of Akkermansia in a probiotic capsule. To receive 20% off your first purchase of Pendulum’s Akkermansia probiotic supplement, go to and use code MARK20.

Topics Covered

  • What’s the point of living long?


  • Learnings from my travel through the Blue Zones


  • Five converging trends that will change our thinking of medicine and health


  • The root causes of aging


  • Influence your genes to reverse your biological age


  • How to eat to extend your lifespan


  • Practices and supplements to support healthy aging


  • Regenerative medicine therapies and protocols


  • What the Yamanaka factors teach us about aging


  • Reimaging how we deal with trauma


1 of 10

Host & Guests

Back to Content Library
Ep. 571 - The Secrets Of Activating Your Longevity Switches