The Causes Of Resistance To Weight Loss

Episode 610 1h 1m


For decades, I’ve been on a mission to help my patients understand that weight loss is not about “calories in, calories out”. There are a multitude of factors that play into how our body makes, stores, and burns fat and the actual amount of calories we eat is one small drop in the bucket of our complex biology.

Today, I’m excited to talk with Dr. Casey Means about the main drivers people face when struggling to lose weight and what we can do about them. We dive into our conversation sharing the main issues most people miss when trying to lose weight, especially if their bodies seem to be resistant to weight loss. Macronutrients like protein, fat, and carbohydrates get most of the attention in this area, but micronutrients like selenium, B vitamins, antioxidants, and so many others actually have a dramatic impact on how well our metabolic pathways work.

Another key consideration for weight loss is detoxification, which works twofold. We need to help our bodies detoxify with the right supportive ingredients and we also need to reduce our exposure to toxins, especially those we call “obesogens” that are linked to excess weight due to the way they disturb our hormones and metabolism.

Dr. Means shares some helpful action items for reducing your own toxic burden and explains why it’s a good thing to “Be a weirdo!” How and when we’re exposed to sunlight also impacts our metabolic processes. Dr. Means and I dig into how light affects our biology and how to leverage it in our daily routine. The main takeaway from this episode is that you do have power over your metabolism.


This episode is brought to you by Cozy Earth, BiOptimizers, and InsideTracker. The Doctor’s Farmacy podcast works with a select group of sponsors to allow for ongoing production and allow it to be zero-cost to anyone who wishes to listen to and watch the podcast.

Topics Covered

  • The top reasons for resistance to weight loss beyond food, sleep, stress management, and exercise


  • Obesogens, obesity, and resistance to weight loss


  • Common sources of toxins in our daily lives


  • How toxins negatively affect our health


  • Why detoxification is an important component of weight loss


  • Limiting our toxic exposure


  • The role of micronutrients in resistance to weight loss


  • Tips for grocery shopping for micronutrients


  • The impact of light on our metabolism


  • Using a continuous glucose monitor to improve your metabolic health


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Ep. 610 - The Causes Of Resistance To Weight Loss