How Supplementing With NMN Can Increase NAD levels, Energy, Reduce Inflammation, And Improve Insulin Resistance

Episode 741 1h 18m


NAD has been popping up everywhere, and for good reason. It’s a fundamental driver of our health and longevity, and we’re now learning how boosting NAD levels might offset and improve the effects of aging.

On today’s episode, I’m excited to talk to Dr. Andrew Salzman all about NAD—how it is a key component involved in mitochondrial production, and is a critical substrate for several enzymes, including sirtuins, which play key roles in healthy aging, weight management, metabolic syndrome, and metabolism. We kick off our conversation by talking about the hallmarks of aging and why dysregulated nutrient sensing is the most critical of these hallmarks.

We have four key nutrient sensing pathways in our bodies that work together to protect us from disease and abnormal aging: insulin and insulin signaling, mTOR, AMPK, and sirtuins. Dr. Salzman explains the key relationship between sirtuins and NAD, and how they work together to promote longevity. Unfortunately, NAD production decreases as we age, and that decline is associated with a subsequent decline in our health and vitality, along with all kinds of age-related diseases.

Luckily, the science is also clear that certain NAD precursors, including NMN and NR, can efficiently increase NAD levels. Dr. Salzman explains what differentiates these NAD precursors and why we should be more focused on NMN. Dr. Salzman and I also discuss Wonderfeel Youngr™ NMN, a supplement designed to support healthy aging and overall well-being.

Dr. Salzman talks about the key antioxidants and sirtuin activators in the formula that enhance the effects of NMN, and why that is so important for increasing NAD levels. We also get into diet and lifestyle strategies that increase NAD in the body—exercise, intermittent fasting, adequate sleep, and avoiding physical stressors like environmental toxins.

I hope you’ll tune in to this fascinating conversation!


This episode is brought to you by Rupa Health, BiOptimizers, MitoPure, and AquaTru. The Doctor’s Farmacy podcast works with a select group of sponsors to allow for ongoing production and allow it to be zero-cost to anyone who wishes to listen to and watch the podcast.

Topics Covered

  • How NAD helps us produce energy


  • The science behind how NAD impacts health and longevity


  • The role NAD plays in maintaining health


  • NAD’s multiple functions


  • Preserving NAD levels


  • Where NAD is made in the body


  • How NAD benefits sleep


  • Do NMN and NAD cause cancer?


  • Research on NMN in humans


  • The difference between NMN and NR


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Resources Mentioned

Host & Guests


Automatically generated. Please forgive any typos or errors in the following transcript. It was generated by a third party and has not been subsequently reviewed by our team.

Introduction: Coming up on this episode of the Doctor's Farmacy.

Dr. Andrew Salzman: There are inflammatory changes that are chronic or subacute where NAD is actually regulating the amount of inflammation in the cell. And that has a whole effect on the development of injury to our tissues, cancer development, lack of healing.

Dr. Mark Hyman: Welcome to The Doctor's Farmacy. I'm Dr. Mark Hyman, that's Farmacy with F, a place for conversations that matter. And if you are curious about longevity, which I imagine maybe listening are, and you may have heard about something called NAD or NMN or NR or sirtuins, or supplements that you can take to potentially extend your life and improve your health, you're going to love this podcast..

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Ep. 741 - How Supplementing With NMN Can Increase NAD levels, Energy, Reduce Inflammation, And Improve Insulin Resistance