How To Reap The Anti-Inflammatory and Longevity Benefits Of Astaxanthin

Episode 751 49m


As we age, our body’s natural antioxidant defenses slow down, driving chronic inflammation and diminishing overall health. To combat inflammaging, scientists have been studying compounds that can reduce inflammation and oxidative stress in the body. One such compound is astaxanthin, a powerful, naturally occurring antioxidant with profound anti-inflammatory health benefits.

Today on The Doctor’s Farmacy, I’m excited to talk to David M. Watumull all about astaxanthin and how it helps to combat some of the key hallmarks of aging—inflammaging, mitochondrial dysfunction, and cell signaling. We kick off our conversation by talking about how oxidative stress and inflammation impact health and aging. David shares the top daily habits that hold the key to unlocking our longevity potential.

Common anti-inflammatories target inflammation unnaturally— without addressing the root cause of the issue or by shutting down the immune system. That may be fine for short-term use, but it’s not safe for long-term use. David and I talk about how astaxanthin naturally targets inflammation at its source, restoring cellular health. In addition to reducing inflammation, astaxanthin supports joint and muscle health, promotes heart health, supports cognitive function, and improves immune function.

We also talk about astaxanthin versus other antioxidants and what makes it so effective at maintaining cellular integrity. For example, it is 6000 times stronger than vitamin C, 550 times strong than vitamin E, and 40 times stronger than beta-carotene. We explore the FOXO3 gene and what role it plays in longevity. Only one in three individuals have a version of the FOXO3 gene that is tied to longevity.

David explains how astaxanthin activates this gene. We’ve all consumed astaxanthin from seafood, but the levels needed to support optimal health and longevity are hard to achieve from diet alone.

David and I discuss AX3, an astaxanthin supplement designed to support healthy aging and overall well-being. David talks about the difference between synthetic and natural astaxanthin and how synthetic astaxanthin offers significant advantages compared to astaxanthin from microalgae, krill, or other natural sources.

I hope you’ll tune in to this fascinating conversation.


This episode is brought to you by Rupa Health, MitoPure, Sunlighten, and Thrive Market. The Doctor’s Farmacy podcast works with a select group of sponsors to allow for ongoing production and allow it to be zero-cost to anyone who wishes to listen to and watch the podcast.

Topics Covered

  • Steps to reduce and manage oxidative stress and inflammation


  • How astaxanthin targets key hallmarks of aging


  • Lifespan benefits of astaxanthin


  • How astaxanthin benefits joint, muscle, cardiovascular, and cognitive function


  • Where astaxanthin is found in nature


  • The FOXO3 gene


  • Astaxanthin for longevity and healthy aging


  • Synthetic vs. natural astaxanthin


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Resources Mentioned

Host & Guests


Automatically generated. Please forgive any typos or errors in the following transcript. It was generated by a third party and has not been subsequently reviewed by our team.

Introduction: Coming up on this episode of The Doctor's Farmacy. David Watumull: Importantly, astaxanthin actually crosses the blood-brain barrier, so it gets to the brain, gets into the cells, and helps to reduce oxidative stress and inflammation. Dr. Mark Hyman: Welcome to The Doctor's Farmacy, I'm Dr. Mark Hyman. That's farmacy with an F, a place for conversations that matter. If you're interested in longevity and natural molecules, and how they interact with their biology to activate longevity pathways, I think you're going to find this conversation interesting, because it's about a particular molecule, widely found in nature that has remarkable properties called astaxanthin. You might have heard about it or maybe you haven't, but you certainly have eaten salmon, which is orange, and that's what you're eating. That's what's..

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Ep. 751 - How To Reap The Anti-Inflammatory and Longevity Benefits Of Astaxanthin