The Science Of Increasing Lifespan And Optimizing Healthspan

Episode 824 1h 12m


Increased human life expectancy is one of the greatest breakthroughs in modern history. We have more than doubled the global average in the last 100 years, but the length of our healthspan, the time we spend in good health, has not increased at the same rate. With the population of people over 60 expected to almost double from 12% to 22% between 2015 and 2050, we have an urgent need to find novel solutions for healthy aging.

On today’s episode of The Doctor’s Farmacy, I’m excited to talk to my good friend Dr. Peter Diamandis about how we can apply the latest science and technology in the field of longevity to optimize not only how long we live but how vibrant and healthy we remain as we age. We kick our conversation off by diving into the concept of longevity escape velocity—where breakthroughs in science and medicine could extend our healthspan by more than a year for every year we remain alive. Our bodies, as intricate and resilient as they are, often mask the early and middle stages of disease.

This hidden progression is a silent threat, one that can suddenly manifest in life-threatening conditions. Consider these startling statistics: 70% of fatal heart attacks occur without any prior symptoms, and similarly, 70% of deadly cancers are those not routinely screened for in standard medical practice. This stark reality underscores the urgency of proactive health monitoring. Peter and I discuss the most important diagnostic tests to track to measure your rate of aging and health and how to use personalized medicine to get ahead of issues and disease before they fully develop.

We also spend some time talking about Ozempic. I share my thoughts about the pitfalls and risks of this drug and we explore the question of whether Ozempic is also a longevity medicine. Navigating the complexities of health and longevity is a journey that requires careful consideration and personalization, so Peter and I explore some of the prescription medications that work and don’t work for increasing healthspan and longevity and what Peter’s personal longevity regimen looks like. In addition, we discuss how the molecule rapamycin, various peptides, supplements, and cutting-edge technologies like Therapeutic Plasma Exchange are all coming online.

We also dive deep into how to turn the latest science into actionable steps and habits you can use now—the best strategies for what to eat, how to exercise, and how to optimize sleep for longevity. Peter is literally the author of a practical playbook on longevity, and our conversation today will leave you with actionable and free tips to set yourself up to benefit from the leading research in the field of longevity and give you a look into the next generation of therapeutics. I hope you’ll tune in to learn more.


This episode is brought to you by Rupa Health, Joovv, Sunlighten, and Cozy Earth. The Doctor’s Farmacy podcast works with a select group of sponsors to allow for ongoing production and allow it to be zero-cost to anyone who wishes to listen to and watch the podcast.

Topics Covered

  • The power and importance of one’s longevity mindset


  • Staying alive and healthy enough to reach longevity escape velocity


  • Debunking the myth that genetics are the main predictor of lifespan


  • Do’s and don’ts of eating for health and longevity


  • The best exercises for longevity


  • Optimizing sleep


  • How not to “die of something stupid”


  • Peter’s personal “Longevity Practices” and cutting-edge technologies coming online


  • My thoughts about Ozempic


  • XPRIZE Healthspan


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Resources Mentioned

Host & Guests


Automatically generated. Please forgive any typos or errors in the following transcript. It was generated by a third party and has not been subsequently reviewed by our team.

Introduction: Coming up on this week's episode of the Doctor's Farmacy,

Dr. Peter Diamandis: 7% to 30%, and there are different studies giving different numbers of your potential. Lifespan is a function of your genetics. The vast majority, 70 to 90% is a function of the choices you make your lifestyle.

Dr. Mark Hyman: Welcome to the Doctor's Farmacy podcast, a place for conversations that matter. I'm Dr. Mark Hyman, and today we have the privilege of talking to one of the leading thinkers and doers in the world, Dr. Peter Diamandis. If you care about learning the practical steps to increasing your health span and your lifespan, you're going to love this podcast. Peter is a serial entrepreneur, futurist, technologist, New York Times..

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Ep. 824 - The Science Of Increasing Lifespan And Optimizing Healthspan