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Episode 48
The Doctor's Farmacy: House Call

The Functional Medicine Approach To Oral Health with Dr. Todd LePine

Open the Podcasts app and search for The Doctor’s Farmacy. If you’re viewing this site on your phone, you can just tap on the

Tap the subscribe button and new shows will be added to your library.

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Oral health is connected to full-body health in myriad ways. In fact, conditions ranging from obesity, diabetes, cardiovascular disease, rheumatoid arthritis, inflammatory bowel disease, and even dementia are all directly connected to poor oral health. In this episode, Dr. Hyman speaks with Dr. Todd LePine about how to address dental health from a functional medicine perspective. They discuss everything from basic oral hygiene to mercury fillings to root canals, and more. They also discuss cases they’ve treated in which there was a link between the patient’s oral health and their systemic health.

Dr. LePine graduated from Dartmouth Medical School and is Board Certified in Internal Medicine, specializing in Integrative Functional Medicine. He is an Institute for Functional Medicine Certified Practitioner. Prior to joining The UltraWellness Center, he worked as a physician at Canyon Ranch in Lenox, MA, for 10 years. Dr. LePine’s focus at The UltraWellness Center is to help his patients achieve optimal health and vitality by restoring the natural balance to both the mind and the body. His areas of interest include optimal aging, bio-detoxification, functional gastrointestinal health, systemic inflammation, autoimmune disorders and the neurobiology of mood and cognitive disorders. Dr. LePine teaches around the world, and has given lectures to doctors and patients at American College for Advancement in Medicine (ACAM), Age Management Medicine Group (AMMG), the University of Miami Integrative Medicine Conference, The Kripalu Center in Lenox, MA, and is on the faculty for American Academy of Anti-Aging Medicine (A4M). Dr. LePine is the head of the Scientific Advisory Board for Designs for Health and a consultant for Diagnostic Solutions Laboratory. He enjoys skiing, kayaking, hiking, camping and golfing in the beautiful Berkshires, and is a fitness enthusiast.

This episode is sponsored by Belcampo and BetterHelp.

Right now, you can order Belcampo’s sustainably-raised meats to be delivered to your door using my code HYMAN at Belcampo.com/Hyman for 20% off for first-time customers.

BetterHelp lets you get affordable counseling anytime, from anywhere. As a Doctor’s Farmacy listener you can get 10% off right now by going to betterhelp.com/drhyman.

In this episode, Dr. Hyman and Dr. LePine discuss:

  • The link between oral health and diseases such as Alzheimer’s, dementia, diabetes, cancer, and many more
  • Traditional vs. biological approaches to dentistry
  • The dangers of metal fillings
  • Root canals
  • The connection between the mouth and the gut
  • How gluten can lead to weakened tooth enamel
  • Improving oral health through diet and nutrition
  • The Role of the Gut Oral Microbiome in Systemic Health

I hope you enjoyed this conversation as much as I did. Wishing you health and happiness,
Mark Hyman, MD
Mark Hyman, MD

Guest

 
Mark Hyman, MD

Mark Hyman, MD is the Founder and Director of The UltraWellness Center, the Head of Strategy and Innovation of Cleveland Clinic's Center for Functional Medicine, and a 13-time New York Times Bestselling author.

If you are looking for personalized medical support, we highly recommend contacting Dr. Hyman’s UltraWellness Center in Lenox, Massachusetts today.

 
Dr. Todd LePine

Dr. LePine graduated from Dartmouth Medical School and is Board Certified in Internal Medicine, specializing in Integrative Functional Medicine, and is an Institute for Functional Medicine Certified Practitioner.  He has been practicing Functional Medicine for over 15 years focusing on Optimal Aging, Bio-Detoxification, Gastrointestinal Health, Systemic Inflammation, Autoimmune disorders and the Neurobiology of mood and cognitive disorders.

Show Notes

  1. The International Academy of Oral Medicine and Toxicology (IAOMT)
  2. Tooth & Gums Tonic
  3. Therabreath
  4. Whole Health Dentistry: Why Your Mouth Is The Key To Your Body's Health
  5. Wellness Dentistry Network
  6. The Broken Brain Podcast – The Importance of Dental Care in Whole Body Health with Dr. Steven Lin
  7. Are Root Canals Dangerous? with Dr. Rouzita Rashtian, DDS
  8. Clean Mouth, Clean Brain
  9. Functional Dentist Directory

Transcript

Dr. Todd LePine:
There are a host of conditions, including premature birth, obesity, diabetes, cardiovascular disease, rheumatoid arthritis, inflammatory bowel disease, and even dementia that are directly connected to poor oral health.

Dr. Mark Hyman:
Welcome to The Doctor’s Farmacy. I’m Dr. Mark Hyman. That’s Farmacy with an F, F-A-R-M-A-C-Y, a place for conversations that matter. And if you’ve ever struggled with dental issues or mouth issues or gum issues or teeth issues, you better listen up because we’re going to have a conversation today about how your mouth health and your oral health connects to your overall health and why it’s so important to focus on oral health. And it’s with none other than my colleague and friend, Dr. Todd LePine, who has been with me for 25 years, working together at the UltraWellness Center. Before that at Canyon Ranch. And he’s one of the pioneers in functional medicine and a brilliant man, and I’m so excited to be back here with you on The Doctor’s Farmacy, Todd, to talk about the mouth.

Dr. Todd LePine:
All right. Thanks, Mark, for having me. You look like you’re in the Castaway movie with the…

Dr. Mark Hyman:
Yeah. Tom Hanks just walked up the beach. Yeah.

Dr. Todd LePine:
Exactly, exactly.

Dr. Mark Hyman:
Okay. So, most people who go to medical school, we don’t really learn much about the mouth. We learn, oh, you’ve got gum disease, or you can have sores in your mouth, I mean, a few things here and there. But it’s just amazing how much of a vacuum in our education oral health is. But as it turns out, it’s been linked to everything from Alzheimer’s to heart disease, to cancer, and to autoimmune diseases, and on and on and on. And the question is what is going on with the connection between our oral health and our overall health? So take us down that pathway. Then we’ll talk about basically how to address dental health from a functional medicine perspective.

Dr. Todd LePine:
Yeah. So Mark, just a little bit of background. I probably have mentioned this before, but I come from a family of dentists. So my grandfather was a dentist. He went to the University of Maryland in the late 1800s. My father went to University of Maryland in 1940. My brother went to UPenn Dental School, and then his two sons are dentists, and my two sisters are dental hygienists. So this is a topic that’s near and dear to me, and I’m sort of the black sheep of the family.

Dr. Todd LePine:
We know that in functional medicine, the gut is sort of where everything starts, and it can either lead you down the path of health, or it can lead you down the path of disease. And the beginning of the gut is the mouth. So as you mentioned, in medical school, we didn’t learn anything about the mouth. That was for the dentist. We’ll just ignore that. And the dentists just basically stay in the mouth, and they don’t really realize that there’s a whole body connected to the mouth, or some of the dentists don’t. And this is where I think a lot of both even functional medicine physicians and dentists really miss a connection.

Dr. Todd LePine:
So unless you’re working with a holistic, smart dentist or a functional medicine doctor who’s aware of the connection between the mouth and the gut and the systemic immune system, you’re going to be missing a lot of things. And as you mentioned before, there are a host of conditions, including premature birth, obesity, diabetes, cardiovascular disease, rheumatoid arthritis, inflammatory bowel disease, and even dementia that are directly connected to poor oral health.

Dr. Mark Hyman:
It’s incredible. Yeah, I mean, dementia. And they’re finding that the microbes in the mouth get absorbed and then go up into the brain and create inflammation in the brain.

Dr. Todd LePine:
Absolutely.

Dr. Mark Hyman:
Pretty wild. We know that your risk of having heart attacks is higher if you have gum disease. We know that even weight and metabolism are related to what’s going on in your mouth. So what’s wrong with traditional dentistry and its overall approach? Because your dentist does your teeth cleaning. They might treat your gum disease. They’ll fill your cavities. They’ll stick in root canals. So tell us what is the problem with traditional approaches to dentistry?

Dr. Todd LePine:
Traditional dentistry… And dentistry has gone a long way. The original dentists were actually barbers. Remember that. The barbers used to pull the teeth out, and the dentists have come a long way since being barbers. But Mark, dentists are what we call drill and fill, and then you can do root canals, and then you can do implants and those kinds of things. A lot of that’s related to structure, function, and cosmetics. People want to have white teeth, and you don’t realize, okay, just because you have white teeth doesn’t mean you have a healthy oral microbiome.

Dr. Todd LePine:
And you really have to look at the whole picture because the beginning of digestion starts with your mouth, starts with healthy saliva. And all of those things are interrelated to being able to digest and absorb your nutrients from the get-go. You need to have a proper salivary pH. You need to have a sufficient amylase. So there’s a lot happening in the mouth that is the beginning of digestion.

Dr. Mark Hyman:
All right. So, one of the challenges in traditional dentistry is they use certain techniques that we find problematic, for example, putting in silver fillings or mercury fillings. And recently, you sent me a link to the FDA’s new ruling that fillings were not acceptable for pregnant women and babies and kids. So why is it good for the rest of us?

Dr. Todd LePine:
It’s not good. It’s not good for the rest of us. And the thing is, the interesting thing about that is that, I think as you said before, there’s no safe level of mercury. Mercury is a known neurotoxin, and some people are better able to detoxify it. My father is an example of that. My father, he practiced dentistry up until his 80s, and he used to literally handle amalgam in his hands, and he’d be throwing it on the floor. And I can remember going to his office and playing with the mercury in his office.

Dr. Todd LePine:
And lo and behold, there are some people who are better at detoxifying mercury, and there are others that don’t detoxify mercury as well. But mercury is definitely, for some people, a real problematic issue, I think as you experienced that yourself. And there’s testing that we do for mercury. You can check for mercury body burden, and you can check for both organic and inorganic mercury. One of the labs, Quicksilver, that we use does that test. And it can tell you how you’re excreting both organic and inorganic mercury. And the one from fillings is the inorganic mercury, which is the more toxic to the brain.

Dr. Mark Hyman:
Right. So we’ve got the filling problem, which really nobody should ever have silver fillings. And if you have them-

Dr. Todd LePine:
No. No.

Dr. Mark Hyman:
… it’s tricky. Do you get them out? Do you not get them out? How do you determine when? I think you need to know that there are biological dentists who do it safely, and there’s a website called iaomt.org. I can put it in the show notes, iaomt.org, which is a resource of learning more about biological dentistry and finding a biological dentist in your area who knows how to practice safe removal and other dental techniques that actually help to rejuvenate your mouth. One of the other challenges is root canals.

Dr. Todd LePine:
Oh, absolutely. Oh, yeah.

Dr. Mark Hyman:
And I think people are getting a lot of root canals. I certainly had one, and I had to take it out. But tell me, what is the problem with root canals? Why should we be concerned? And should everybody with root canals have their teeth pulled, or what do we do?

Dr. Todd LePine:
All right. So, I’m not an endodontist who does root canals, and I’ve spoken with my family members about this. And if somebody is really, really skilled at doing a root canal, you can do a root canal. But I think the key thing about root canal, doing a root canal, is to make sure that you’re dealing with a sterile environment, which is very, very difficult in the mouth, because when you’re doing a root canal… My sister, Gail, she made a comment that a root canal is basically a dead tooth. And if you had a dead spleen, would you leave a dead spleen in your body? No, you want to remove a dead organ.

Dr. Todd LePine:
And a tooth that’s devitalized doesn’t have nerves, so if you get an infection, you oftentimes won’t get pain unless it starts surrounding to the other area. You don’t have a lymphatic system to drain infections. You don’t have a blood supply, arterial and venous supply. So you can really get these stealth infections. And by that, we typically think of an infection as someone who’s got a fever, there’s swelling, et cetera, but you can have these smoldering infections. And I’ve seen… Just this past week, I’ve had two patients who had a history of root-canal issues that were manifesting as systemic issues, and they really didn’t have a whole lot of oral issues. They were having peripheral issues.

Dr. Mark Hyman:
Yeah, that’s interesting.

Dr. Todd LePine:
Exactly. Yeah. And then when they open those root canals up, if it’s a bad root canal or a root canal gone bad, they often find these anaerobic infections, and they are foul-smelling. The anaerobic bacteria produce things like putrescine and cadaverine, and you don’t want a lot of cadaverine in your body unless you’re a cadaver, and putrescine is very, very, very foul-smelling.

Dr. Mark Hyman:
It doesn’t sound good either.

Dr. Todd LePine:
And there’s a lot of… Yeah, you’re right. And there’s a lot of organisms that are in the mouth. In fact, the oral organisms, and we have hundreds of oral organisms. There’s about a 45% concordance between the bacteria that we find in the mouth and the bacteria that we find in the digestive tract. And you can think of the whole body as being like a tube. And the opening of the tube starts at the mouth, and then it goes all the way down into the stomach, the small intestine, the large intestine, and then out the anus. And those bacteria that are in the mouth get swallowed by the body. I mean, you will swallow about 10 billion bacteria per day. And some of those bacteria, when you swallow them, can actually cause systemic inflammation, and systemic inflammation can manifest in the joints, in the heart, or in the brain. It can also promote systemic inflammatory diabesity, as you well know.

Dr. Todd LePine:
So it’s a real important issue, and it’s not just having, okay, my teeth look white; everything’s fine. You can’t see the types of bacteria that you have in your mouth. And not only that, but your individual immune response to the bacteria is really critical. And we know that in terms of with like, say, for example, COVID. COVID is a virus. And as a virus, for the vast majority of people, it’s not going to kill you. You get it, and you may be totally asymptomatic, you may have a mild cold, or you may die from it.

Dr. Todd LePine:
The same thing with certain types of bacteria. Everybody’s immune system is unique. And when certain people are exposed to certain organisms at critical levels, it provokes a low-grade inflammatory response or, in some cases, actually even more acute, and that can lead to a whole host of systemic issues.

Dr. Mark Hyman:
Yeah, I think that’s true. And I think both of us have seen patients who, when addressing their dental issues, often resolve other systemic issues. So maybe you can share a little bit about some of the patients you might have seen that have links to their systemic health from their oral health.

Dr. Todd LePine:
Oh, absolutely. I have three cases. Real briefly, the first case is a patient who actually was a friend of mine. And I remember we were talking over a beer, and he was telling me some of his health issues. And he was bemoaning the fact that he was having all these symptoms and nobody could figure it out. And I said, “Well, why don’t you come see me? I’ll do a consult on you, and we’ll take a look at it. That’s sort of what I do.”

Dr. Todd LePine:
And he told me, in going over his history, that he had a Cadillac in his mouth. And I said, “What do you mean you have a Cadillac in your mouth?” “Yeah, I’ve got about $40,000 worth of dental work in my mouth.” And he goes, “The dentist said I have weak enamel.” And I said, “Well, what do you mean weak enamel?” And I said, “Weak enamel is not normal.” I said, “Did he tell you why you have weak enamel?” And the first thing that popped into my head is that he probably has undiagnosed celiac disease, which can cause weak enamel.

Dr. Todd LePine:
And lo and behold, I tested him, and sure enough, he had a marked response to gluten. And when he got off of it, I mean, a lot of his symptoms… It didn’t affect his teeth because the horse was already out of the barn. But he also was having sort of unexplained fatigue and malaise and all that kind of stuff, and actually, just getting off of gluten cleared up those other conditions. And you and I well know that there are multiple autoimmune conditions that are associated with gluten sensitivity, but weak enamel is one of those things. And I try to get my patients and the dentists who I see either as patients or dentists who I meet in social circles to really be aware of that because I just think it’s below everybody’s radar.

Dr. Mark Hyman:
It’s incredible.

Dr. Todd LePine:
Yeah. And it was very life-changing for him. Another case is a patient who I saw who was diagnosed as having rheumatoid arthritis. And this is a woman over from Europe, and she wasn’t getting anywhere in the European system, not that the European system is better or worse. It’s just different than our system. But she was not getting any significant help over there, and they wanted to use the disease modifying anti-rheumatologic drugs, or the DMARDs. And when I did a workup on her, I did a deep dive in her, and she had seropositive rheumatoid arthritis. And by seropositive meaning that when you check for rheumatoid arthritis, you can have a positive rheumatoid factor, or you can have a positive CCP antibody or both of them, one or the other, or both of them. You can also have seronegative rheumatoid arthritis.

Dr. Todd LePine:
And as we talked about earlier, rheumatoid arthritis is just a label that we put on things, and lots of different things can cause rheumatoid arthritis. The most virulent, aggressive type of rheumatoid arthritis is the one that has both RA positive and CCP antibody positive. Now, if you go into the medical literature, CCP antibodies are associated with periodontal disease. So anytime I see a rheumatoid patient who’s got a positive CCP… There are other things that can do that. Epstein-Barr virus can do it also. But it’s strongly associated with the periodontal disease, and then I have to start doing a deep dive.

Dr. Todd LePine:
So what I did with her is I did a deep dive, and lo and behold, she had a lot of dental issues. She had old root canals. She had silent infections. I did as much as I could, and then I also referred her to a very good colleague of mine, Doug Thompson, who runs the Wellness Dentistry Network out of Michigan, and he helps to teach other physicians about integrative dentistry. So I referred my patient to see him, and he did all the different things that he did. In addition to having rheumatoid arthritis, she also had undiagnosed Lyme disease.

Dr. Mark Hyman:
Ah.

Dr. Todd LePine:
Exactly. So she had two things going against that can affect the joints. So I basically treated her Lyme disease, did that successfully over a period of time. Had her see an integrative dentist. We did testing on her oral microbiome. He did his thing, and she had a dramatic improvement. She also really changed her diet. And all of those factors really, really made a huge difference in her life. She was basically not able to function. And when we treated the underlying causes, the root causes, she had a dramatic improvement in her health.

Dr. Todd LePine:
And then one other case, and this is a really anecdotal case, and I really like this case. And Mark, you probably have seen some patients, or I’m sure in your career that you’ve seen a lot, is a patient who has a frontotemporal dementia.

Dr. Mark Hyman:
Yeah.

Dr. Todd LePine:
Right, and that’s a bad thing. It’s like Lewy body. We don’t really understand these kinds of conditions. And I saw the lady, and she was actually quite advanced with her frontotemporal dementia when I saw her. And I did a big workup. I did the ION test, nutritional metabolic testing, testing for leaky gut, testing for heavy metals. And actually at the time, I did a relatively new test, which is the MyPerioPath test, which is looking at the DNA of the oral microbiome. And she had one of the worst oral bacterial microbiome analysis that I’ve ever seen. And my hypothesis was is that I think her frontotemporal dementia was really being driven by undiagnosed severe periodontal disease that was spreading up to her brain.

Dr. Mark Hyman:
You just said a mouthful there because… I just wanted to highlight a couple of things. One, there is an oral microbiome.

Dr. Todd LePine:
Yes.

Dr. Mark Hyman:
Just like there’s an intestinal microbiome, and that has implications for your health. And there’s ways that now we can test this, and this is not something you’re going to get at your traditional doctor. It’s what we do here at the UltraWellness Center that’s so unique. We sort of dig down below the layers to see what’s really going on. There’s also genomic variations in our own DNA that affect our risk of periodontal disease. And there’s also tests we can look at to look at the heavy metals in the mouth and see if the mercury in your fillings is getting off-gassed and if you’re absorbing it and detoxifying it or not. So there’s a lot of tests that we do in functional medicine that can be very helpful to identify whether the issues you’re having are oral.

Dr. Todd LePine:
Yeah, absolutely.

Dr. Mark Hyman:
Yeah. So the other thing is what do we do to change our diet to keep our gums healthy and keep our teeth healthy? And what do we know about food and nutrition and oral health, and then, of course, basic lifestyle hygiene stuff that we should all be paying attention to?

Dr. Todd LePine:
Yeah. So I actually, Mark, when I prepared for this, I made a couple of slides which should be available as an add-on for the podcast, for those who want to look at it. But the big thing is the introduction in the diet, in the modern-day diet, the standard American modern-day diet, is the introduction of acellular starchy fiber or foods. And when you think of this, it’s very simple to think of it. These are the things like rice crackers and pretzels. They basically have very little nutritional value. And then sugars. The modern American diet is very high in these types of foods. And these types of foods are basically instant sugar, and they feed the oral bacteria, and those bacteria also will multiply in the body. We obviously know that you can have bacteria that can cause dental caries and do tooth decay, but it can also feed some of these other pathogenic bacteria.

Dr. Todd LePine:
And you mentioned the role of the various types of bacteria. There’s a couple of bacteria which I like to see on the MyPerioPath test, which is Fusobacterium nucleatum, and then another one which is a real bad actor, which is the Porphyromonas gingivalis. And these organisms are in the mouth, and you’re swallowing them. So the diet that you eat will feed both the bacteria in the mouth and then also the bacteria in the gut.

Dr. Todd LePine:
So some simple things that you can do is avoid snacking, drink water after you’ve had a meal, watch for processed carbs, sort of fake food, if you will, in your diet. Chewing xylitol gum is actually something that is a simple thing to do that can actually have an anti-dental-caries type of an effect. And then using an electric toothbrush; that’s another thing that is a simple thing to do. I pretty much recommend that for all my patients. And you can use that right after you eat. And then also having lots of fiber in your diet. When you’re eating fiber, it basically is cleaning the teeth.

Dr. Todd LePine:
And we all know… We’ve all woken up in the morning with that film over our mouth. Well, that film is actually a biofilm. And unless you’re actually keeping your oral hygiene clean, you’re going to get some slime on your teeth, and that’s really where the bacteria really sort of take hold in the mouth. And a good integrative dentist will actually work on oral biofilms also.

Dr. Mark Hyman:
That’s great. And often, there’s a lot of things we can do to improve our oral health through supplementation. Things like CoQ10 is very important. Proanthocyanidins from colorful plant foods. Vitamin C for gum disease. Even things like vitamin D to help the bone structure and prevent osteoporosis in the jaw, which can cause weak teeth and so forth. So there’s a lot of things you can do to actually help improve your overall oral health.

Dr. Mark Hyman:
One of the things that I loved was developed by a friend of mine, who was a dentist in Lenox years ago. It was called the Dental Tooth and Herb Gum Tonic. And essentially, it’s a series of herbs, and it was amazing. He basically showed me. He would scrape my mouth, and he would put it on a slide, and he’d show all the little bugs swimming around. And I’d do the dental swish with this Dental Tooth and Gum Tonic, this Herbal Tooth and Gum Tonic, and it was just totally different. And all the bad spirochetes and things that are causes of gum disease would improve. So there’s a lot of simple things you can do, from obviously an electric toothbrush to Waterpiks and flossing, to using these different kinds of herbal tonics that can really help to keep your teeth and gums healthy. And it is really important because your oral health is so connected to your overall health.

Dr. Todd LePine:
That’s interesting that you mentioned that, Mark, because I… There’s a-

Dr. Mark Hyman:
You probably knew him. Remember? He was in Lenox years ago. I forget his name.

Dr. Todd LePine:
I don’t remember, but you know what? There’s a company. I believe it’s up in New Hampshire. I don’t know if it’s the same company, or there’s another company that uses… It’s like a tooth tonic, if you will, which is an anti-microbial. So yeah, that’s actually quite interesting. The other thing is, which I’ll mention, because this is… It sounds sort of hokey, but it’s actually, it’s in the medical literature. In fact, preparing for the talk, I actually looked on PubMed, and there’s an article from 2020 about oil pulling and the benefits of oil pulling on the oral microbiome and oral hygiene. So you can do that with a variety of different oils. You can do it with coconut oil. I don’t know if you’ve ever done it, Mark, but it also leaves the mouth with a very clean taste, a very clean feeling in the body. And then that also comes out to the other aspect of the oral hygiene, is halitosis. So if somebody has really bad-

Dr. Mark Hyman:
Bad breath. Bad breath.

Dr. Todd LePine:
Yeah, bad breath, exactly. So bad breath is not just an embarrassment. It’s telling you that you’ve got some bugs in there that are producing chemicals that are not very good for your body. And these are usually some of the bacteria that can actually reside in the tongue and the tongue fissures, and they’re what we call sulfite or sulfur-reducing bacteria. And there’s a dentist who came up with a product, which is a very effective one. It’s called TheraBreath, which I oftentimes will have patients use. And that’s a very effective way of dealing with halitosis, but then also then looking at, okay, how can we actually improve the oral microbiome in addition? And there are some products that are out there with some Lactobacillus salivarius and such that are oral probiotics to also help balance out the microbiome.

Dr. Mark Hyman:
Yes. So probiotics for your mouth as well, is what you’re saying.

Dr. Todd LePine:
Yes, exactly. Yep.

Dr. Mark Hyman:
Yeah. So from a functional medicine perspective, we really deal very differently through diet, through nutritional supplementation, through various herbal therapies, and other things that can actually help us. And we also focus on the big issues that are somewhat controversial, which is heavy metals in the mouth and mercury, and even root canals can be a problem. I don’t think all root canals are a problem for everybody.

Dr. Todd LePine:
Right.

Dr. Mark Hyman:
But they can become infected, and it’s often missed. And I personally had a root canal that I knew wasn’t quite right. The dentist thought it was fine. The endodontist, she didn’t have a problem with it. The x-rays looked fine. And I ended up having a cone-beam x-ray, which is a special type of CT scan of your tooth. It’s much more accurate in determining whether there is some pathology there. And I definitely did have an infection, a low-grade inflammation infection at the top of my tooth. So I had it pulled, and it was really… We sent the tooth off to the lab, and it was frightening to see what was growing in there.

Dr. Todd LePine:
Yes. Yeah.

Dr. Mark Hyman:
So this is really a new frontier of oral health and systemic health, and I think we really don’t pay enough attention to it in medicine.

Dr. Todd LePine:
Absolutely. Yeah. And there’s an interesting… When I was first made aware of this, I went into the medical literature just to see if there’s anything in the literature. And in PubMed, there’s a case of one, of a patient who had, quote-unquote, rheumatoid arthritis. And when the patient had a tooth removed, they had a closed dental infection, and the patient’s rheumatoid arthritis went into complete remission.

Dr. Todd LePine:
Interestingly, my brother, Eric, who’s a dentist, he actually had an anecdotal case himself because he had this patient, and he took the patient’s bad tooth out. I think it was a old root canal. And the patient came up to him afterwards and said, “You know, doc, after you took care of my tooth, I feel so much better. I can move now, and I’m not in pain.” And sort of a light bulb went off in my brother’s head to say, “Yeah, there’s really a connection here.” So it’s good. And I think we just have to raise the awareness of it for both doctors and dentists and also patients.

Dr. Mark Hyman:
Yeah. It’s not to say that all root canals cause a problem, but it’s important to identify the fact that for some, it can be. And for not all people dental fillings are a problem, but for some it can be. So I think we have to be very personalized in our approach. And I’m really thrilled that we got a chance to talk about oral health. It’s not something that doctors really talk about. And there are a lot of great resources out there. I’ve learned a lot from the holistic dentists out there. I’ve learned a lot from some of my colleagues, like Mark Breiner, who’s written a book called… I think it’s called Whole Health Dentistry. And I think we can learn a lot about how to improve our overall health by keeping our oral health in check.

Dr. Todd LePine:
Absolutely. And one other thing which I’ll mention, because we talked about the testing that we do, which really is helpful to sort of… My motto is, “Test, don’t guess,” because when you have objective information from the labs, it helps to really direct what to do. And one of the new tests that I’m using now is a test called DNA Smile, which is a really interesting test. It’s looking at genetic variations. And at the UltraWellness, we do a lot of genetic testing to look at a person’s variations in their genes. None of these genes are related to disease.

Dr. Todd LePine:
And this is a fascinating profile because it looks and sort of can risk-stratify a person’s risk for developing periodontal disease. So it looks at markers related to the immune system, innate immunity, acquired immunity, whether or not a person tends to want to have sweet foods, sort of have that sweet tooth, how they can detoxify, and then also whether or not they have issues with the ApoE4 genotype, which is related to lipids and Alzheimer’s disease. So I’ve been using this test to really sort of preempt, to see, okay, does this person have the genetic profile that can push them in the direction of someone who’s going to be getting periodontal disease?

Dr. Mark Hyman:
Exactly. Well, I’m so thrilled about this conversation, and I think people need to pay more attention to their oral health and understand, as a functional medicine perspective, there’s ways we can diagnose problems and help people. Todd, it’s been great having you back on The Doctor’s Farmacy. If you love this podcast, please share it with your friends and family. Leave a comment. Tell us about how you’ve tackled your oral health issues. Subscribe wherever you get your podcasts, and we’ll see you next week on The Doctor’s Farmacy.

If you are looking for personalized medical support, we highly recommend contacting Dr. Hyman’s UltraWellness Center in Lenox, Massachusetts today.

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