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Episode 499
The Doctor's Farmacy

Can We Live Healthy Forever? The Frontiers Of Longevity Science

Open the Podcasts app and search for The Doctor’s Farmacy. If you’re viewing this site on your phone, you can just tap on the

Tap the subscribe button and new shows will be added to your library.

If you’re using a different device, our show is available on the following platforms.

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Just five years ago, the concept of age reversal was considered crazy. Now, it’s the hottest topic in research, as we continuously discover exciting interventions that can actually reverse our biological age. 

I’ve experienced these amazing advances firsthand—chronologically I’m 62, but my biological, or “inner” age, is only 39. 

And I’m not the only one who’s become fascinated by the science of age reversal and reaped the benefits. Today on The Doctor’s Farmacy, I talk to Tony Robbins and Peter Diamandis about their research and personal journeys in aging backwards using a range of simple, accessible interventions and the latest health-tech. 

They recently released a book together, along with Dr. Robert Hariri, called Life Force: How New Breakthroughs in Precision Medicine Can Transform the Quality of Your Life & Those You Love.

I’m so excited to talk to Tony and Peter about their work on this incredible book, which I enjoyed every single page of. They share their personal experiences in becoming passionate about this field, through overcoming injuries and symptoms of aging with the most groundbreaking technologies out there. 

The study of precision medicine for age reversal is all about going upstream of chronic disease. It’s not about specifically focusing on Alzheimer’s, diabetes, or any of the other chronic diseases plaguing us. It’s about teaching the body to use natural substances or processes it already knows, to generate, repair, revitalize, and enhance what we already have and avoid those diseases in the first place.  

Sirtuins, stem cells, NAD+, NMN, sleep, diet, exercise, and nutraceuticals are just some of the many areas of reversing biological age that we get into throughout our conversation. I know you’ll find it all as fascinating as I do!

This episode is brought to you by Rupa Health, Eight Sleep, and Cozy Earth.

Rupa Health is a place where Functional Medicine practitioners can access more than 2,000 specialty lab tests from over 20 labs like DUTCH, Vibrant America, Genova, and Great Plains. You can check out a free, live demo with a Q&A or create an account at RupaHealth.com.

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I hope you enjoyed this conversation as much as I did. Wishing you health and happiness,
Mark Hyman, MD
Mark Hyman, MD

Here are more of the details from our interview (audio):

  1. The physical injury that inspired Tony to write this book
    (5:45 )
  2. Redefining our concept of aging
    (19:10 )
  3. Understanding how to modify genes to reverse aging
    (21:10)
  4. New diagnostic testing to inform us about our health
    (36:36)
  5. Simple ways to enhance your longevity and health
    (45:01)
  6. Sleeping, eating, and fasting for longevity
    (48:05)
  7. Exercising for longevity
    (54:08)
  8. How mindset affects aging and longevity
    (1:00:20)
  9. Three things that lead to emotional mastery
    (1:06:31)
  10. Nutraceuticals, supplements, medicines, and other new therapies to enhance health and longevity
    (1:13:06 )

Guest

 
Mark Hyman, MD

Mark Hyman, MD is the Founder and Director of The UltraWellness Center, the Head of Strategy and Innovation of Cleveland Clinic's Center for Functional Medicine, and a 13-time New York Times Bestselling author.

If you are looking for personalized medical support, we highly recommend contacting Dr. Hyman’s UltraWellness Center in Lenox, Massachusetts today.

 
Tony Robbins

Tony Robbins is an entrepreneur, #1 New York Times bestselling author, and philanthropist honored by Accenture as one of the top 50 business intellectuals in the world. Robbins is a leader called upon by leaders: He has consulted with and/or coached some of the world’s greatest athletes, entertainers, Fortune 500 CEOs, and four US presidents. Robbins is a founder, partner, or early investor in 100+ privately held businesses with combined sales exceeding $7 billion annually. Through his philanthropy and partnership with Feeding America, he has provided more than 800 million meals and is on track to provide 1 billion meals by 2025.

 
Peter Diamandis

Peter Diamandis is the founder and executive chairman of the XPRIZE Foundation, which leads the world in designing and operating large-scale incentive competitions. He was recently named by Fortune as one of the “World’s 50 Greatest Leaders.” He is also the executive founder of Singularity University, a graduate-level Silicon Valley institution that counsels the world’s leaders on exponentially growing technologies. 

Show Notes

  1. Get a copy of Life Force: How New Breakthroughs in Precision Medicine Can Transform the Quality of Your Life & Those You Love
  2. Sign up for the Longevity Insider Newsletter

Transcript

Introduction:
Coming up on this episode of the doctor’s pharmacy.

Tony Robbins:
So we know our DNA is not our destiny. The metaphor we try to share with people is, their DNA is the plan. It’s like the piano, the epigenome is the piano player turning on and off.

Dr. Mark Hyman:
Welcome to Doctor’s Farmacy. I’m Dr. Mark Hyman and that’s Farmacy with an F, a place for conversations that matter and if you care about living well and living long, and avoiding the ravages of aging and having a vibrant long life, well, this conversation’s going to be for you because I have two extraordinary guests today, Tony Robbins and Dr. Peter Diamandis. Tony, you probably heard of. He’s a number one New York Times, best selling author, he’s a philanthropist, he’s one of the top 50 business intellectuals in the world. He’s called upon by leaders all over the world, presidents and CEOs, Fortune 500 leaders, great athletes, entertainers. He’s the founder partner of early investor in over a hundred privately held businesses with sales, exceeding seven billion dollars. He does incredible philanthropy. All the money from his new book, Life Force is going towards Feeding America. And he has literally provided 800 million meals to people, trying to get to a billion by 2025.

Dr. Mark Hyman:
And Peter, is an old friend as well, who is just an extraordinary man who believes the world is full of abundance and possibilities. He’s written a book called Abundance, which I love. He’s a founder and executive chairman of the X Prize, which leads the world in designing and operating large scale incentive competitions you’ve probably heard of some of them. For example, the Space X Prize you’ve probably heard of and he’s now got one on aging longevity on greenhouse gases and climate change. He’s just incredible. He’s one of the world’s greatest 50th leaders according to Fortune. And he’s also the executive founder of Singularity University, which is a graduate level Silicon Valley institution that counsels the world leaders on exponentially growing technology. We’re going to talk about exponential growth, which is where we’re at with longevity. So welcome Tony and welcome Peter. I love you both and actually, you know what? I actually read this entire book, which is no joke. It’s almost 700 pages, cover to cover, every word [crosstalk 00:01:58]. Every word of it.

Peter Diamandis:
Going to give you a PhD for that. Yeah.

Dr. Mark Hyman:
I mean, I’m just going to be honest okay. Well, my new commitment is radical honesty or compassionate radical honesty and normally I have a guess and I’ll skim the book. I’ll read a lot, a bit of it. Some less, some more. I literally read this cover to cover. And Tony and Peter, I really want to start with a big picture, which is Tony, why were you inspired to write this? Why were you inspired to pull together Peter and Bob Harari, who’s another extraordinary physician in longevity science to write this book called Life Force?

Tony Robbins:
Most of my life I’ve been obsessed with answering the question, how do you increase the quality of people’s lives? How do you enhance that? And there’s only a few areas that matter. There’s your body, obviously your mind, your emotions, your relationships, your career, your business, hopefully a mission and the spiritual side of life. So I’ve always been invested in all those areas. And I’ve been a bio hacker myself, because the demands of what I do. I go 12 hours at a time, 3, 4, 5 days in a row with 15,000 people who wouldn’t sit for a three hour movie, you got to keep their attention. I’ve learned a lot about the body over the years. But the real impetus for this book was because about four and a half years ago, I had several experiences, but one of them was really severe.

Tony Robbins:
I was being an idiot going down the side of a mountain, snowboarding chasing a 22 year old, near professional snowboarder who could clearly do things I couldn’t do. And I had a crash, I thought I broke my neck, but I tore my rotator cuff so severely that, I’ve lived a lot of pain in my life, but it was nine, nine pain on a zero to 10 scale. And I didn’t know what to do, so first I had to figure out I couldn’t even sleep. It was an hour and 15 minutes one night, an hour another, I got a PEMF pulse electronic magnetic and frequency device, which took the pain down. There’s about 3000 studies on this now of bone healing, nerve healing. It took the pain to like a five where I could sleep.

Tony Robbins:
But then I had to figure out the solution. Of course, I went to all the traditional doctors and I went to, I think four, actually five in the end. They all recommended immediate surgery. And when I talked to some of the people, he said, I even asked those doctors, what’s the prognosis? Will I be able to fully do everything? They said, “Well, you could, but you may not be able to raise your arm above your shoulder.” “And how long will I have to recover?” “Well, four to six months. Four months if it goes well, six months if it doesn’t. It could tear again.” “I could tear again?” So, I’ve always been a person that says there’s got to be a better solution and I hang out with this guy, I had this genius over here. And so I called Peter because he’s my dear friend and he knows everything in technology and he is so health oriented as well.

Tony Robbins:
And I said, “Listen, I’ve read all this about stem cells. All these doctors when bring it up, they all say, it’s bullshit. It doesn’t do anything. And then I’ve heard other people rave about it. Where would I go to go at the best source?” And he said, “Well, you should go talk to Dr. Bob Harari.” And I go, “He’s a neurosurgeon.” He goes, “Yes, but he’s one of the greatest fathers of stem cells. He did those original studies 38 years ago where they gave old rats, young blood and we all know what happened. They got younger and vice versa.” So I met Bob and it’s like saying, you want to learn about basketball let me introduce you to Lebron James, my friend that’s [inaudible 00:05:02] right? And Bob made it clear, he said, “Tony, you don’t want to do stem cells through your own body.” Otologist because stem cells drop off the cliff in 40, 45 years old. And obviously in my early fifties. And he said, “You need the force of life.” That’s why I call it Life Force.

Tony Robbins:
He said, you need young stem cells literally that are four days old. And he said, “You will need placenta or you need cord stem cells.” And I said, “I don’t want to do fetal tissue.” He said, “No, no, no. It’s not fetal tissue. When babies are born, they tend to throw these away. Now some people save them.” And he told me where to go, I went down and I did three days of stem cells. It was just an IV and a shot. They told me in advance, you might feel tired. I did, I felt sleepy. No problem. The second day I had a cytokine response, which I knew what it was so I wasn’t scared. A little shaking and freezing for about 20 minutes. And then they said, “Well, that often gives you a bigger reaction.” And I go to sleep. I left out the most important thing. The last doctor I talked to, he’d been all my work and told me how great it was so I changed his life and made the most money and saved his marriage.

Tony Robbins:
And then he looks at me and says, “But now, because I’m a doctor, I have to shoot you straight.” He shows me my spine, he goes, “Life as you know it is over.” I said, “You clearly didn’t go to my communication seminar.” Right. But I laugh about it now. But I said, “What do you mean?” He goes, “Let me show your spine.” And he goes, “You have severe spinal stenosis,” he said, “One good hit from a snowboard. One good jump when you fall that, any of these things,” he goes, “You have to change your life completely.” And if you were ready for it, you can take a good punch in the gut. I got to be honest. It took me down for a couple hours. My brain’s like what’s happening in my life. And then my brain kicked back in and said, this is BS and that’s when I reached out to Peter.

Tony Robbins:
So on the second day of these stem cells, I woke up with no pain in my shoulder. I’ve done the MRI since then, everything’s fine and it was like four years ago. It’s totally fine. And I’ve no challenge whatsoever. No surgery. But the most unbelievable thing is for 14 years, I had massive back pain from the spinal stenosis. I woke up with no back pain. I still don’t have it. I became just an evangelist, I want to know everything about stem cells. And then Peter was going over to the Vatican, where the Vatican every two years has this conference where they bring in the best of regenerative medicine. That’s how far it’s come. Because the Pope sees it’s not fetal tissue so I want the best doctors. This is healing humanity. And then they invited me to be the cleanup speaker. And so I was like, “I’m not going to go just be a cleanup speaker. Peter already invited me to go.” I was like, “I’m going to go for the full four days and then my cleanup will really serve people.”

Tony Robbins:
Peter and I both sat there and learned things that just blew our mind. I saw this person that Bob had worked on this 11 year old boy that I think he was four, when he was told he had like a 6% chance to live. Whatever the percentage was. He wasn’t supposed to live but Bob convinced the parents to get stem cells from the daughter that’s just being born, saved his life. Saw people that were sent home to die or sent to hospice and they wouldn’t give up and they did Car T-cells and I’m sure you saw Dr. June in nature this week it came out. There were actually, cancer guys don’t talk about cure but they’re calling it a cure. Because 10 years later, those Car T-cells are still wiping out cancer in their body. It’s just amazing. And so after seeing all these breakthroughs, I was like in my own experience. And I met Jack Nicholas there and we developed a relationship and he was supposed to have his, he couldn’t stand for more than 10 minutes without massive pain.

Tony Robbins:
So here’s a guy, the greatest golfer of all time, can’t golf, can’t play tennis, can’t do anything. They wanted to fuse his spine. And I’m sure you know less than 50% of the time does that work. 26% of the time those people never make it back to work. 76% of the people that don’t do it, get back to work. Thank God he didn’t do it. He did stem cells instead. Now he is 82 years old and he is playing tennis and he is playing golf again with no pain. Right? So I said, I’m going to write this book. This is what I’m good at. I go get the best like I did with Money Master The Game, interviewed the fifties, smartest billionaires in the world that started with nothing, figure out what they do. I’m going to do this with 150 doctors. But who could I write this better with than Peter and Bob?

Tony Robbins:
I went to them and said, “Listen, this is what I want to do.” I convinced them let’s just to do it. Why don’t you join me on this journey? And so we’ve been working our tails off every bit for three years. Two and a half years in the middle of COVID trying to figure out how to wrangle all these doctors so we could get the information we did. But we’re really proud of it. Because what we discovered, I’ll just give you a highlight and I know you’ll take us deeper, but I mean think about it. We all know or have heard about CRISPR now and Peter’s a genius in this area, he can give you more details. But we’re literally curing disease with gene therapy and with CRISPR. I mean, there are people that haven’t been able to see that have their sight back. Stem cells are curing problems within people in a matter of days.

Tony Robbins:
Cristiano Ronaldo gave me a quote for the book because he had this calf pull, not a soft one, a severe one, right. Could take him a month or two. He was healed in two and a half weeks using stem cells. Right? So you turn around and you see now today there’s a company out there that’s in stage three trials, but just so your audience does phase one is safety, phase two is efficacy, phase three is efficacy scale. They’re on the third phase right now. They believe they’re going to prove early next year. If they do a single injection causes the part of your body called the wind pathway to create your own stem cells and re-roll your tendons in 11 months. And they’re based on a clean epigenome. So you get like 16 year old tendons, even if you’re 50 or 60 years old.

Dr. Mark Hyman:
That’s amazing.

Tony Robbins:
Dr. Sinclair is a mutual friend of all of us. He’s a genius in longevity. He’s 53 chronologically, but he’s 33 years old in his biochemistry because we don’t age at the same level. We’ve been applying that, I just did my test. I’m 62 in a few weeks, but I’m 51, which is nice. I want to get that down to early forties. And then there’s these diagnostic tools, so we’re living in the greatest time to be alive. I’m a guy that had, one of the first cell phones, that’s how old I am. It weighed two pounds, it was a foot long, it cost $4,000 to be 10 grand today. You had to be in a place where you could charge it for six hours to 30 minutes of talk time. Now you got an apple phone, you can get it for free with a service contract. It’s got a hundred times the power of what took the [inaudible 00:11:04] to the moon and back.

Tony Robbins:
So that as you know is happening in medicine, but most people don’t know that’s happening. So we wrote this book to show you what you can do to make yourself stronger, healthier, more vital, be able to change the trajectory of your health span or longevity and also deal with some of the biggest diseases and challenges and how prevent them. And so we’re excited and we’re like I said, we’re donating all the money to make a difference. 20 million meals to feeding America and the balance is going for Alzheimers, cancer, heart disease and aging research with some of the greatest researchers, so people can get these answers, but they can also help somebody else simultaneously.

Dr. Mark Hyman:
Well that’s so perfect Tony. I love that story, why you’re inspired to do it and I think Peter and you and I, are all about the same age, I’m 62 and stuff starts to break down.

Tony Robbins:
Yes.

Dr. Mark Hyman:
And I was told also that I had to have a spinal stenosis, a spinal surgery, a spinal fusion that I would be basically incapacity for a year. I couldn’t function. I had three back surgeries. I literally couldn’t move. And I-

Tony Robbins:
Wow. I didn’t know that Mark.

Dr. Mark Hyman:
Yes. I did the same thing as you. I got to regenerative medicine specialist, I got exosomes, some placental matrix and all kinds of goodies injected in my back, worked out with my Tom Brady training program. And I’m literally stronger than I’ve ever been. I literally just beat a bunch of 30, 40 year olds at a plane competition.

Tony Robbins:
That’s awesome.

Dr. Mark Hyman:
My biological age is 39 and my friends can’t keep up with me they’re in their thirties and forties. And I play tennis, I go helicopter skiing. I’m stronger, fitter and faster than I’ve ever been because I’m taking advantage of these new technology and the science that’s pushing us all. Was chatting with Peter before we started, I’m like, “Okay, you know well now I’m 60. We’re kind of basically starting to figure life out and get happy. Right?” You got to deal with all the crap of like making your career and your family and all this stuff and meaning and purpose. I be like, “Okay, I made it.” And then, it’s not time to wind down, it’s time to wind up. And I feel like what your book and with you and Peter and Bob has done is really mapped out one, what we know now about the science of longevity and aging that’s not being applied. Stuff that works right now that we can do, we’re going to go over that.

Dr. Mark Hyman:
Two, what are some of the extraordinary technologies that are emerging in the science? And some of them might prove to be, false, or some of them might actually be life changers like the cancer therapies or the 10 injections. WNT pathways you mentioned. And you’ve also provided a map for people to navigate the landscape of what’s out there that’s encyclopedic, and I’ve never seen anything like it out there. And I’m in this field, I pay attention to it closely. I read everything out there and your book does something that nothing else has done, which is really create an entire kaleidoscopic view of this field, where we are, where we’re going and where we’re going to get to be. And It’s so exciting.

Dr. Mark Hyman:
I mean, I was talking to my friend, I want to get to be 120 or a 100. I’m like, “No, I think maybe I’m going to do 180 now.” And then Peter, is talking about longevity escape philosophy. If you keep leaving long enough, you keep extending life. So maybe there’s no end insight. I don’t know how you feel about that, but this is just tremendous. So that was a great-

Peter Diamandis:
This the most amazing time ever to be alive. Yeah.

Tony Robbins:
Oh, yeah.

Dr. Mark Hyman:
And Peter, your mind Peter is so extraordinary because the way you think is really different. And Tony, you really taught people how to think about their psycho, emotional, spiritual lives in a really profoundly different way that has impacted so many. I think I bought my first Tony Robbins cassette tapes in 1990. And I listened to them in Idaho when I was a family doctor. And Peter I’ve known for decades and I’ve just been in awe of his ability to dream and I think-

Tony Robbins:
[crosstalk 00:14:41] What I know about Peter though is, he doesn’t just dream. I don’t mean to step on you there. I know you know this about him but I want your audience to know, he doesn’t just dream this man executes. And he brings the best tools and technology and so many things that we did here is like I didn’t even know about. Some of them we knew about, some neither one of us knew about. But it was like this incredible set of discoveries as we found more and more of these researchers, but Peter is probably the most network person on finding solutions that I know of. He’s just the genius in that area. I didn’t want to let you know how important he is-

Dr. Mark Hyman:
I agree. It’s not just about… [crosstalk 00:15:12] One sec, I just want to say this one quote, because it speaks to what it’s emblematic of Peter, which is Robert F. Kennedy’s quote. He said, some men and it should be people, right? Some men see the way things are and ask why others dream of things that are not and ask why not. Right. And so I might have bungled the quote, but it’s something like that.

Tony Robbins:
Oh, that’s real close. That’s Peter.

Dr. Mark Hyman:
It’s Peter. It’s like you-

Tony Robbins:
That’s why I hang out with this guy, I know I like to hang out with geniuses. Even Bob.

Peter Diamandis:
I’m going to make sure my mom gets to watch this episode.

Dr. Mark Hyman:
So Peter take us through some of the foundational concepts, cause there’s a lot of really wonderful sciences emerging. It’s not quite ready for prime time. Take us through what we know now about the fundamentals of longevity, because this is not stuff you’re necessarily hearing at your doctor’s office. And it’s redefining our whole framework of aging from being just a normal process, right? Oh, we look around us and we say, “O God, everybody gets sick. Six out of 10 Americans have a chronic illness. Four out of 10 have two or more, 80% of us are overweight. 88% of us are metabolic unhealthy. I mean, it’s just we live in a terrible world. So who wants to be old and [inaudible 00:16:23] and die and nobody wants to do that. So you’re presenting a different view, which is that aging is not normal. How we see it today in this world, it’s actually abnormal aging.

Peter Diamandis:
It’s exciting Mark. So let me begin by giving context about even the concept of aging. Our bodies, there are 40 trillion cells in our body. And our bodies evolved as homo sapiens hundreds of thousands of years ago. And if you go think back in time, we would go into puberty at age 13. And by the time we were 14, we were pregnant. And by the time you were 28, your baby was having a baby. And that was the cycle of life. The challenge was back then food was scarce. There was no McDonald’s, no whole foods. And the worst thing you could do, if you wanted to perpetuate the species was take food out of the mouth of your grandchildren. So you would die. Human body was never truly meant to live past age, 30, 35, maybe 40. A hundred years ago, the average lifespan was just under 40. Today, it’s risen up into the high seventies and the early eighties.

Peter Diamandis:
And because we had a short life, there was no selective pressures against the diseases that we would have as we age. So there was no selective pressure against heart disease or cancer or dementia, because no one ever lived long enough to have those things. And today we’re realizing that we don’t have to accept the genetic deck of cards that we were dealt over the last hundred thousand years, because we’re beginning to get the tools that could allow us to modify those. To identify and understand what isn’t working and where we’re going. Now here’s another question which I know, you know the answer to, but for people listening, you’ve got the same genome when you’re born as when you’re 20, as when you’re 40, 60, 80, or a hundred years old. You’ve got the exact same genome, 3.2 billion letters from your mother and 3.2 billion letters from your father. Why do you look different? Why don’t you have the six pack that you had when you were a teenager, right? And the same quality-

Dr. Mark Hyman:
You have a keg instead.

Peter Diamandis:
Well, it turns out it’s not your genes. It’s which genes are turned on and which genes are turned off. It’s your epigenome epi from the Greek word above, it’s the control of the genes. And so if you look at the genome of a 20 year old, and if you could move that time, go through time to a 60 year old person the same person, you just find different genes are on and different genes are off. And the work that’s being done, and we talk about, Tony and I highlighted a number of really heroes in the book. Bob Harari is one of the heroes we talk about, Carl June from Car-T therapy we talk about.

Peter Diamandis:
But David Sinclair and his work in understanding the epigenome and some pivotal work he did in December of 2020, published the cover of science, that he was able to reverse the age of the visual systems of mice who had lost their sight because they age. He didn’t just treat them, he made them biologically younger. He was able to use what are called three of the Yamanaka factors. These are the four Yamanaka factors. Dr. Yamanaka won the noble prize for this being able to take your skin cell and de differentiate it back into a [potent 00:19:57] stem cell. Well four factors bring you all the way back, three factors brought you back to a youthful state and since then-

Dr. Mark Hyman:
Wait, wait. Just to stop you there for a second. Just so people are listening, get what you’re saying. Basically there are these regulatory factors that control how your genes work, that can take a skin cell or a liver cell or any cell on your body and bring it back to its original embryonic state where it can become anything else, which is radically changing our view of how we can regenerate our health and actually extend life. So these amino effects are a big deal. We’re still figuring out how to use them, what to do with them. They’re a little bit confusing, but it’s just radically shifting our view, which is we literally have within us the code of a baby. How do we activate that code and we program-

Tony Robbins:
And what’s interesting with those mice is their glaucoma. So the nerves are gone, you don’t regrow nerves in the brain, but by doing that reversal, they regrew them back and could see. It’s first time in history it’s happen to them. I’m sure it’ll get nominated for Nobel prize. It’s pretty extraordinary.

Peter Diamandis:
It is. And then the work was done about six months later to do the same type of biological age reversal in the heart of mice. And now George Church is taking into dogs and the expectation is that we’ll start to see this kind of technology in humans before the end of this decade. So to frame it properly, the entire conversation about age reversal, not longevity, because you can’t truly prove longevity unless we’re able to live 50, 60 years and say, “Well, this person now got to 150.” But can you actually reverse age biologically measuring the epigenome we’ll get to those epigenetic clocks in a moment. But the conversation was crazy five years ago. And today it’s the hottest subject of research.

Peter Diamandis:
And we’ve just seen incredibly in this one year alone, we saw the crowned prince of Saudi and of Abu Dhabi fund a multi-billion dollar foundation called Evolution that is investing in longevity and age reversal. We saw Yuri Milner and Jeff Bezos fund Altos Labs to hundreds of millions, clearly eventually billions of dollars. We saw the founder of Coinbase start a company. So we’re seeing massive amounts of capital flowing in, right? And the money-

Dr. Mark Hyman:
Not from the international institutes of health, unfortunately, which is only about out of-

Peter Diamandis:
I’d rather trust the entrepreneurs to solve this problem and not the government.

Tony Robbins:
One of the interesting things Mark too for your listeners, one of the things that David discovered was, I’ll give it to you in the simple non-doctor frame. There’s a couple terms that will be useful ones. We know our DNA is not our destiny. The metaphor we try to share with people is, their DNA is the plan. It’s like the piano, the epigenome is the piano player turning on them off. But these seven sirtuins, these seven master genes do two things that are critical. Two radically different things that are competitive a little bit, because as you probably already know, your stem cells drop off on your forties and the source of fuel for these sirtuins drop off on your fifties. But these sirtuins the first thing they do is they turn on off the effect the epigenome, which genes get turned on and off, whether you’re going to get ill or not, whether you’re going to age or not is affected by it.

Tony Robbins:
They also affect inflammation, which is we all know as a basis of so much of disease and they also affect your mitochondria, the source of energy in your body. They feed it. They make it possible to generate that energy. Now the other competing aspect is as we get older, we accumulate challenges in our DNA because of radiation, chemicals, all things we’re exposed to. [crosstalk 00:23:34]. So it’s funny you got a certain level, at 60 you got a lot more. And the metaphor that Bob often uses trying to explain, even with stem cells is, imagine you have this mansion, you have these great young staff members who fix everything all the time and would always looked beautiful, but as they get older and then all of a sudden you don’t have the same resources and things to go fix in your age. Well, these sirtuins they’re supposed to clean up your DNA. That’s what they do.

Tony Robbins:
But their source of fuel is something I’m sure you’ve heard of and lots of people heard of are called NAD+. That’s the fuel. If you don’t have that fuel, sirtuins can’t do their job. And guess what, NAD+ drops in your fifties through the floor by at least 50%. So now you’ve got this competing thing when you need most of your DNA cleaned up and your energy strong and inflammation dealt with and your genes there, it’s all breaking down simultaneously. But the good news is, I’m sure you know there’s a precursor to NAD+ that allows it to go on the cell and maximize, and that’s NMN, never mother never. Well, Peter and I, our company, we went out and we knew the power of NMN because it’s one of the things that Dr. Sinclair uses, one of his four core elements that’s made him chronologically younger. He’s got his 80 year old father transformed through this. So we’re quite excited about it.

Tony Robbins:
But if you go out in the marketplace, you can find them from 35 bucks to like $120 but we haven’t found at six companies, any NMN left. And I was like, “I talked to our guys, it’s like coming from China, are these people just thieves?” And they said, “Well, they could be. But more likely it breaks down in 30, 45 days.” So here’s the cool thing, there is some NMN that works right now and that means all of this-
PART 1 OF 4 ENDS [00:25:04]

Tony Robbins:
Here’s the cool thing. There is some NMN that works right now, and that means all of this can be restored and you can make this change in your body where you get the energy and the DNA clean up so you can have sustained health, but there’s a company called [Micro-Biotech 00:25:12]. The founder of this has collected about 100, very much like Altos and others, some of the greatest people in regenerative medicine.

Tony Robbins:
We got chance to meet him, hang out with him. He’s become a friend of mine. He’s actually coming here again on Saturday. He has created a crystallized version of NMN that doesn’t break down. But it’s even more powerful. Think of this, so your audience appreciates this. If you take an old mouse, a 70 or 65, 70-year-old mouse is as about 20 months old and you put him on a track and they try and go. The most they can hit usually is a quarter of a kilometer, whereas a young mouse can do a full kilometer four times as much. After 14 days on just this traditional NMN, they can run two to three kilometers, literally two to 300 times more than a young mouse.

Tony Robbins:
But here’s what’s unbelievable. You go, “Well, yeah, but…” I always go, “My studies don’t always transfer to humans.” Well, this company, Micro-Biotech, unbeknownst to anybody else has been working on a top secret project with our armed services, specifically with the Special Forces. They did a two year study and the commander got so excited he dropped the beans and it got exposed. He talked to a reporter. Last week, it was in the Daily Mail, but their reporting is still not the real full details. I can’t tell you those either. We’ve invested in the company. We know some of the details, but I can tell you this. They just got their initial results back and it’s unbelievable. Similar experiences, think of the most fit people in the world, both men and women, Special Forces now with greater endurance than they’ve ever imagined, building muscle faster with the same exact exercises and increased cognitive capacity.

Tony Robbins:
Now, they’ve got… I think they’re in phase three right now beginning on a COVID test for preventing that. Because as you know, COVID comes into the mitochondria and sucks the energy out of it, right? Creates massive inflammation. And that’s so far looking really good. They’re doing some on kidneys because that’s the other challenges with COVID, and this looks like a huge breakthrough, but this will not be a nutraceutical. This is going through the FDA. Right now, the FDA is pairing up what they’re doing with the military so they hope to have this out in 18 to 24 months. I mean, these are the types of breakthroughs that none of us could have even dreamed of [inaudible 00:27:21].

Dr. Mark Hyman:
What you both are talking about, I want to take a minute and zoom out for people because what you’re talking about is not curing Alzheimer’s, or heart disease, or cancer, or diabetes, you’re talking about going way upstream to deal with the root causes of all of it. And so we’ve been doing Whac-A-Mole medicine by trying to whack down these different diseases by different pathways and different drugs and finding a cure for cancer, the cure for Alzheimer’s, [inaudible 00:27:43] we spend billions of dollars and then over 400 studies on Alzheimer’s and come up with nada, nothing. [crosstalk 00:27:49]. Let me finish for a second. So the key to think for people is that by looking at aging differently, by looking at… What you’re talking about, Tony, is you’re not actually treating a disease. You’re actually teaching the body using natural substances or things the body already does or already programmed into our DNA to regenerate, repair, renew, revitalize, and enhance what we already have and make us younger without treating disease.

Dr. Mark Hyman:
In functional medicine, I don’t treat disease. I help people enhance their function. That’s what it is. That’s exactly what functional medicine is. Yes, it’s important to know what disease has. And yes, you need some drugs to help people who’ve already gone way down the path. But for most of us, these therapies, your back was a fricking mess, mine was a mess. And yet, somehow we figured out using these therapies to regenerate our tissues and revitalize ourselves so we’re stronger like the Bionic Man at 62 years old, right? [crosstalk 00:28:41].

Peter Diamandis:
The take home lesson here is aging is a disease itself and it’s the single core commonality between all diseases. And the conversation that’s changed, we talk about in the book Multiple Places is the idea that aging is a disease that can be slowed, stopped, and for the first time ever rationally thought about being reversed. There’s this concept called longevity escape velocity, which you mentioned a little bit earlier, [Mark 00:29:11], which I love. Today, we’re in this period of massive exponential growth where AI computation, sensors, networks, robotics, 3D printing, synthetic biology, all these technologies are doubling in power every 18 to 24 months. They give you miraculous things like this conversation we’re having today right now for free. It’s awesome. It’s also changing the course of the human lifespan, the health span.

Peter Diamandis:
Today, we’re gaining about a quarter of a year for every year that we’re alive about three months. There is a point in which science is going to all of a sudden for every year that you’re alive extend your life for greater than a year. That’s called longevity escape velocity. I’ve heard about this term for a long time. I went and started asking people who I consider in the know when they think we’re going to hit this. Our forward for the book is written by Ray Kurzweil, who’s one of my mentors and dear friend of Tony’s, my co-founder of Singularity University, and Ray’s prediction is that we’ll see escape velocity in about 12 to 15 years time.

Dr. Mark Hyman:
Wow. We’ll be in our 70s.

Peter Diamandis:
Which is just around the corner, right? And so-

Tony Robbins:
Right when we’re all going to need it.

Peter Diamandis:
Exactly. Listen, we’re living in a video game. Don’t ever forget it. We’re get down at the last level of gameplay. But then I went to someone who is extraordinary. One of the other heroes in my book, Dr. George Church, a friend, professor of genomics at Harvard Medical School. He has started 24 companies in 24 months. Just brilliant beyond belief as an entrepreneur and a core scientist. I was having the same conversation with him for this book and asked, “So George, when do you think we’re going to see longevity escape velocity?” I expected him to say 30 years, 20 years. Probably about within the next 15 years. And I’m like, “I’m oh my God, that’s extraordinary.” Now two points don’t make a proof of it, but from two different perspectives. So if that’s true, if we have the ability to reach this departure point of longevity escape velocity in 15 years, all of our jobs is to reach that point to not die.

Dr. Mark Hyman:
We want to follow the Bee Gees song Staying Alive.

Peter Diamandis:
Yeah, Staying Alive. Our job is not to die from sending stupid in the interim, right?

Dr. Mark Hyman:
Yeah. [inaudible 00:31:42] cancel my helicopter skiing trip then?

Peter Diamandis:
Wear a helmet at least. At least wear a helmet.

Tony Robbins:
That brings up, Mark, diagnostics, as you know, which I think is so critical. I had a different philosophy. I really want to acknowledge Peter for this because Peter’s like, “I want to know everything.” And I was like, “I don’t know if I want to get in that system of knowing anything. People overreact to things.”

Tony Robbins:
But today, going to a physical where somebody taps your knee, looks down your throat, listens to your heart, checks out your ears and makes you cough, that’s about 80 years old. Nothing wrong with it, but it’s far from what we really have today. And so you look around at diagnostics today and most of the people in the book that are these heroes, the one common denominator they almost all have is they’ve lost somebody they love, a husband, a wife, a child, or maybe a patient they really connected to, and it drove them to not just accept the standard of care.

Tony Robbins:
One of those is a gentleman who created GRAIL, which is, you look at cancer right now, the cancer society to study with 100,000 people. They came up with these two round numbers are important to know. It’s more important than the numbers, know that just the direction. That if you are finding something at stage three or four, you got an 80% chance of dying. Now, I’m not big in that. I got a 20% chance of living, let me figure out how. But the point is, it’s a lot harder. If you find it at stage or two, you got an 80 to 99.9% chance of living. And so most of the diseases that kill us with cancer, we’ve got mammograms, we’ve got colonoscopies, but it’s the diseases we have in those tests for. GRAIL is this new blood test that can test 50 different cancers and find them before the symptoms are there. We had a gentleman that came here to Fountain Life, and his wife, he went to a traditional physical and-

Dr. Mark Hyman:
Wait, Tony, what’s Fountain Life? Because people don’t know what that is.

Tony Robbins:
Oh, I’m so sorry. Peter and I are partners with Dr. Kapp and several others. He owns 12 different hospitals and he decided he wanted to get out of traditional care and wanted to do precision medicine. We have centers across the U.S. We’re opening one in Abu Dhabi. We work, for example, in Pittsburgh with the entire Pittsburgh Steelers. It’s all about regenerative medicine. How do you prevent and how do you maximize and optimize what the human body can do? Some people come because they have a problem. Some people come to prevent a problem. But we do, for example, diagnostics there. This man comes to us and he just had his physical, and he did his urinalysis and his blood. His wife just was saying, “You got to do this. These guys have a different level.” Sure enough, we go in and we do the GRAIL test and we do an MRI for what the GRAIL test can’t pick up across the blood-brain barrier and so forth. Sure enough, he’s got kidney cancer, just the beginning of it.

Tony Robbins:
Well, it’s an outpatient process that took 30 minutes and he’s free of cancer versus phase two or phase three, right? Our partner is Dr. Bill Kapp, called me about, I don’t know, five, six months ago, and he said, “Tony, we have first access to one of the greatest breakthroughs in cardiology in the last 10 years.” Dr. Kapp is a… He’s an understated guy, not an overstated guy. He said, “That sounds like a big promise.” I said, “What is it?” He said, “You’ve had CT scan before,” he said, “Yeah.” And he goes, “You’re looking to see what’s your calcium score and we’re trying to make decisions.” And he said, “It’s so hard to read. It’s so [inaudible 00:34:45] even doctors make mistakes. A lot of times surgeries happen that really don’t need to happen.”

Tony Robbins:
He said, “So the breakthrough is there’s a new device called a CCTA scan. What it does is it uses AI and opens up the arteries digitally and goes in and looks for, has this calcium hardened? Which means you’re totally fine. Or is it soft plaque that can break off and be the widow maker that gives you a heart attack or a breakdown in your brain.” And he said, “Tony, it’ll blow your mind.” So I said, “I’m coming, I’ll come in a couple days.”

Tony Robbins:
My father-in-law is with me. This is what so touched me. He’s just turning 80. He’s a self-made man, self-educated guy, worked in the lumber business, a pretty strong guy. But when you’re turning 80, everybody around you is like, “You should arrange your affairs and you never know what’s going to happen.” I could just see his entire psychology change over the last, say, three years.

Tony Robbins:
So I said, “Dad,” I said, “I’m going to go do this test.” I explained it to him. I said, “Listen, we’re both at a stage of life where we’re going to have some soft plaques. It’d be good to know where they are because they tell you where and the amount. And then they give you a… They can predict a heart attack five years in advance. More importantly, they can show what you need to prevent it. Why don’t we do this?” He goes, “All right, I’ll come.”

Tony Robbins:
So we go there. I’m better than I was five years ago. I’m thrilled out of my mind. But my father-in-law is perfect. He’s got no problem whatsoever. His entire psychology changes. And then we have this set of tools that we use a lot on world class athletes. I torqued my ankle on stage years ago, like 15 years ago, the nerves got trapped and nothing we did worked. I tried all kinds of therapy. After a while, just I let it alone, right? If a massage therapist… Don’t touch my ankle, because the nerves would just shoot through me like electricity.

Tony Robbins:
They go in and they use ultrasound, they scan it, they look at the connective tissue. They can see where you’re not getting circulation where the nerve’s trapped. Five minute little intervention and they put the fluid in, it opens everything up. My ankle, I can smack the hell out it, nothing ever happened since. My dad’s there, he just found out his heart’s perfect. He’s got nothing to worry about. And his hip, he can’t walk right. We got some brilliant doctors there. Probably took them 30 minutes to scan it, find it, implement it. Now, he’s walking smooth as silk. We get on the plane. This is my favorite moment with him. He’s got his arms crossed like this and he’s looking at me and he goes, “Ton,” he goes, “I don’t know about those people saying 110, 120, like Peter.”

Tony Robbins:
He goes, “I don’t know if I buy that stuff.” But he goes, “You know what? My heart is perfect. I’m walking perfect. I could live to be 100. That’s 20 more years. You’ve only known my daughter for 22 years. It’s like a whole new life.” His entire mindset changed. I really honor Peter, because he’s always done this. It’s like you should tell him how much data you take in. [crosstalk 00:37:31].

Peter Diamandis:
Tony, I’ve been doing this for five years. I’m going tomorrow, in fact, to Fountain Life. I’m flying over to Naples for my annual upload, right? In five hours, I’ll do the AI-enabled coronary imaging. I’ll do the full body, the brain vasculature MRA, the DEXA scan, the genomics. It’s 150 gigabytes of data. But I’ll tell you, I feel naked until I go and do it. I feel like I don’t actually know what’s going on inside my body. When people say, “Well, I don’t want to know.” Say, “Bullshit, of course you want to know. You want to know because you can actually do something about it now then before.”

Peter Diamandis:
For me, it’s one of the most extraordinary things. We’ve all known people we’ve lost and they show up in the ER with a pain in their side and the doctor pulls them aside and said, “I’m sorry to tell you this, but you’ve got this and this.” And it didn’t just start that morning. It’s been going on for some time, but we’re all optimists about what’s going on inside. It’s time to be realistic about it.

Dr. Mark Hyman:
Well, it seems like there’s two things you guys are really talking about that are real breakthroughs. The first is understanding the root causes of aging itself and how to revitalize human biology and really reprogram us to a younger you. The second is all these incredibly cool technologies that are taking us to a body shop and giving us a 100,000 point checkup and finding all the little things that are off and tweaking them using amazing new technologies that are a little bit downstream. So if you screwed up your hip, or you got a heart thing, or you got this or that, yes, we can still fix it. Like your back and my back, Tony, we did some damage by being crazy and thank God there’s stuff to fix it. We’ve got these two things happening in peril.

Dr. Mark Hyman:
One, we’re actually going to help prevent getting these things in the first place, knowing what we know. And two, we’re going to be able to fix the things that we can’t even imagine are fixable. Like your father-in-law didn’t think he could walk straight or his heart was good or any of these things. This is what’s so exciting. I think when we talk about treating diseases and your book does a really good job of talking about some of the things that we can do about Alzheimer’s, and cancer, and some of the new discoveries and immunotherapy, and it’s all great. We need to be doing all of it. But the truth is if we cured cancer and heart disease, we’d get probably a total of three or four more years of life. That’s it.

Tony Robbins:
That’s right. We talk about that.

Dr. Mark Hyman:
If we eradicate it from the entire planet.

Peter Diamandis:
It’s crazy.

Dr. Mark Hyman:
But with these technologies we’re talking about, we’re talking about not just three to five years, we’re talking about 30, 50, 100 years of extension. That’s mind-blowing. [crosstalk 00:39:58].

Tony Robbins:
There’s also, for people listening, some people that doesn’t interest them. Like when we were at the Vatican, Peter asked, [inaudible 00:40:05] to be 120. Like I said, it’s like two-thirds didn’t raise their hand, and Peter [inaudible 00:40:09]. I said, “Dude, here’s what they’re thinking. He’s old and drooling and not looking good.”

Tony Robbins:
But there are things you can do right now that we already know about, like hormone therapy, actually knowing where your hormones are. Sounds so simplistic. Most women think of it because of going through menopause, but hormone replacement therapy is different than hormone optimization therapy. And so we had a guy who came to Fountain Life. He was 36 pounds overweight, feels like he’s gotten old, brain fog, all these things. We did all his blood, did all his tests, and then we did his hormones. People don’t tell you, I think he was 225. Well, I think around 150, they tell you got a real problem. But most men need seven, eight or 900 to feel like a human. All we did was change hormone therapy, lost the 36 pounds, turned around his business, turned around his life because he felt 10 years younger.

Tony Robbins:
But people wait until the traditional form of medicine is there’s a huge problem. When you can do some simple things, do a test. It’s so inexpensive. And then completely change the quality of your life today and then reprogram to stay younger. And then if there’s a disease, deal with it. But I think it’s important that people know things they can do right now, as well as these incredible breakthroughs that are coming down the pipe that can help us reprogram our body.

Dr. Mark Hyman:
Well, that’s right. What Peter was talking about was the epigenome, right? And we know that it doesn’t take millions and billions of dollars and huge technologies and full body MRIs to affect the epigenome. What affects it is what you eat, the type of exercise you do, sleep, stress, relationships, love. Cuddling actually improves the function of your epigenome, just hugging somebody. That’s so powerful. You talk about all the time how you change your state, changing your state, hormetic therapies like hot and cold therapy, right? Powerful stuff and we can actually use now that the science is there for. And it wasn’t even-

Tony Robbins:
Some of it is so simple. Just like you said, the hot and cold. I start every morning in my cold plunge. But I also, I know about saunas forever. I do a sauna every now and then. But in research for the book we worked with this researcher who is brilliant this area, and you literally four times a week in a sauna. You don’t have to own one. You can go to the gym and you reduce your risk of a heart attack by over 48%, the result of a stroke by 56%. It changes your blood pressure. I mean, and a lot of people can’t imagine going exercising, but they can imagine sitting in as sauna for 18 to 20 minutes. And then all of a sudden they start feeling good. Now, they want to exercise. Now, they want to do other things.

Tony Robbins:
There’s so many little shortcuts in here. Like cancer, who’s afraid of cancer? You look up and you find out broccoli sprouts, there’s 1,000 studies showing how it defends against cancer, an 80% reduction of cancer in breasts for women. Right? It’s got sulforaphane in it. Who would’ve known? Right? It doesn’t cost you a fortune. You don’t have to do a giant medical intervention. I want people to know while there’s these great technologies, there’s also these simple lifestyle things that can change it all. [crosstalk 00:43:02].

Dr. Mark Hyman:
After I read that in your book, I went and bought the broccoli seeds and I have them, but I haven’t figured out how to sprout them yet. [crosstalk 00:43:09].

Tony Robbins:
Hire someone to sprout them for you, Mark. [inaudible 00:43:14].

Dr. Mark Hyman:
Okay, okay, okay.

Peter Diamandis:
You talk about this all the time, Mark, in your work and I think it’s worth just repeating it for folks again. Let’s talk about the basics of sleep, exercise, diet, hydration, mindset, in addition to scanning your body to make sure there’s nothing going on inside, right? First off, we-

Dr. Mark Hyman:
Dive into that.

Peter Diamandis:
So sleep, something that, I used to pride myself on four or five hours sleep when I was in medical school. Today, I pride myself on eight hours sleep, right? I got my Oura Ring. I’m measuring it. I’m making sure I go to sleep early. I’m in a cold 64 degree room with a chilled blanket underneath, eye shades. I don’t watch TV for the hour before. I don’t actually watch TV at all. But sleep is something I’m proud of getting more than ever. Our brain needs eight hours. If we didn’t need-

Tony Robbins:
And ironically, I want to interject just for a second, I’m working on the sleep chapter at 6:15 in the morning and I got to be up in three and a half hours. And I’m like, “What’s wrong with this?” We talked to Dr. Walker, who is head of neuroscience at UC Berkeley, and he convinced me, Peter convinced me to read his book. And then I went, we did our interviews. And the way he convinced me is he said, “Tony, there’s been a 1.6 billion person study.” I was like, “How would you possibly coordinate that?” He goes, “We didn’t. 70 countries have daylight savings time.” And he said, “Here’s what you got to know. When we spring forward and lose just one hour. For the next three days on average in each country, there’s 24% more heart attacks. When we fall back in the fall and get one hour extra sleep, over those three days, 21% reduction in heart attacks.”

Tony Robbins:
He does the same thing with car accidents. Peter and I were both four or five hour guys. My wife loves eight hours. I did same thing. It’s like I work at it now. I got my whoop on and I just make sure I’m in that bed for eight hours. And so I might get six and half hours now, but it’s completely different than the four and half or five, and I feel such a difference when it’s there. And then there are times when I violate it and I pay the price. [crosstalk 00:45:09].

Peter Diamandis:
The second category, food. Mark, you know about this better than anybody. If I were going to say there’s no single diet for… It depends on your genomics where your family of origin is, but there is one thing. There’s one thing that everybody needs to know. That’s that sugar is poison. Sugar causes neuroinflammation, sugar causes cardiac inflammation and cardiac disease. It is fundamentally something the body never evolved to have. We didn’t have sugars when we were growing up on the plains of Africa. It’s a recent invention and it’s addictive and it causes disease in so many ways. The question is, can you eliminate that from your diet? That’s the number one objective that will change your dietetic life.

Tony Robbins:
Well, thank God you got the message, Peter, because I’ve written about 18 books on the topic.

Peter Diamandis:
Like I said, you know about it. [crosstalk 00:45:59].

Tony Robbins:
Once again, there are things you can do, like for people that are overweight. There was a study done in Lancet, two years, and here’s all they did. Eliminate 300 calories a day. That’s a bagel or that’s one of the nice Starbucks that you have. They lost 16 pounds on average and their blood sugar balanced out. I mean, it’s again, most people, I’m one of those people, I all or nothing go so extreme, but there are a lot of ways that you can make these minor changes through time as a new habit. They completely change your biochemistry and the quality of your life.

Dr. Mark Hyman:
Absolutely. Peter, before you go on the next topic, I want to reiterate what you’re saying, because you were talking about NAD, and sirtuins, and this master regulatory system that controls our mitochondria, and our energy, and our gene expression, and inflammation, all these things. I was in a conference at the Menla Center, which is Bob Thurman Center. He’s a Tibetan Buddhist. He had Dalai Lama there, all the Tibetan longevity experts, all the longevity science, Leonard Guarente, who discovered there are sirtuins, David Sinclair, all these guys were there. I’m walking down some country path with Leonard Guarente. I said, “So Leonard, what is the deal with sirtuins? What is regulating them and how do we fix this?” He says, “Well, it’s sugar. Sugar is poison to these things.”

Dr. Mark Hyman:
It turns out that one of the hallmarks of aging is nutrient sensing systems. Sirtuins is one of them. Something called mTOR is another one. CMPK is another one. [inaudible 00:47:20] protein and sugar, but sugar is the poison that actually causes these to disregulate and cause rapid aging all across the board. Peter, you’re so right on this.

Peter Diamandis:
Other things real quick, two liters of water a day, at least keeping yourself hydrated, especially if you’re a caffeine drinker. Lehayim, cheers. And then a whole plant-based diet, Mark, which you write about extensively. Tony, what about exercise? I mean, it’s something that you’ve-

Dr. Mark Hyman:
Well, before you skip on diet, there’s a lot of stuff that you cover in the book. I just want to touch on quickly, which are things like time restricted eating, eating with a narrow window, giving your body a break from the overwhelm of food and the abundance. We eat so many more calories than we did even 50 years ago. And so giving your body time where you’re not eating, whether it’s 12, 14, 16 hours a day, actually trying different things like fasting, [inaudible 00:48:12] diets or ketogenic diets, or intermittent fasting, fasting a day, week, 5:2 diets. There’s a lot of ways to do it. The whole idea is to give your body a rest because when you stop eating is when you activate all those healing repair mechanisms in the body that regenerate and repair and renew yourself. That’s really what we’re talking about here.

Tony Robbins:
I talk to people in seminars all the time and I say, “Where does energy come from?” People yell out food. I say, “Okay. Well, tell me about your last Thanksgiving. Tell me about the meal you had and tell me how much energy you had afterwards.” Right? And then I ask, “How many have you ever gone on a fast for five or six days?” You get maybe 18, 20% of the audience that may have done that. I say, “Okay, get past the first day. I know that’s a rough one. But by day two, certainly by day three, you had no food, does your energy increase or decrease?” Everybody talks about how it increases, right? But unless you have that experience, but [inaudible 00:49:03] approach to this where he’s got this intermittent fasting, 12 hours or 16 hours, depending on how you go about it. In the book, we describe some ways that don’t feel so extreme, but where you can get the same benefit.

Dr. Mark Hyman:
And that’s what we call a hormetic therapy, just like the hot and cold, by restricting, it’s like an [inaudible 00:49:18]. They call it adversity mimetic. They mimic adversity. When the body has a stress, it bounces back stronger, whether it’s cold therapy, or heat therapy, or restricted eating, or different kinds of exercise, which you talked about.

Tony Robbins:
Exercise is the perfect example, as Peter was just saying. It’s like exercise, it doesn’t have to be hard exercise. We did a study, it was done, we had a study in the JAMA and it was saying literally one hour of walking on a treadmill and you reduce your chance of heart attack by 48%. There are some cool things, years ago, I heard about static contraction. They did this study with 35,000 athletes. Mostly people, bodybuilders that are going seven days a week to the gym. They discovered a lot of things, muscle confusion, a lot of cool techniques came out of those original studies 18 years ago. But one thing they didn’t know what to do with initially-
PART 2 OF 4 ENDS [00:50:04]

Tony Robbins:
… Original studies 18 years ago, but one thing they didn’t know what to do with initially that came out, that I got exposed to, was that, inevitably, these body builders would get injured or get sick, and they get injured and most of them were plateauing, because they’re going to the gym six, seven days a week, and most of us know you don’t build muscle while you’re making the stimulus. You make the stimulus. You make it when you sleep and your body’s been stimulated to rebuild, right? So these guys are over training, but no one got it until they saw these guys who would get sick or they get injured, and they come back 10 days off or two weeks off and they do a personal best. So this group created this thing called static contraction. I’ve got long arms, so if you’re doing something like a bench press, I would do 210, 220, something like that. A short guy, a little bit easier, right?

Tony Robbins:
It was never my focus, but I started studying this and what they’d do is they say, look, if a car was coming at you, would you start here with the barbell or the car and then try and push it away? No, you’re going to start out here, so you can use all the muscles. So they do this process, this is what they did originally, where they drop just below bending point, so you’re not locked out, and you have to find a weight that you can hold for 15 seconds, at least five. If you can hold it for 15, you’ve got to go heavier. Well, my first way of doing this static contraction, I was 425 pounds.

Tony Robbins:
I took a woman, who was doing this for a while, who was 62 or three years old. She looked a little older, gray hair, and I took her to Gold’s Gym to film her, and there was this 25 year old kid with a ponytail and really built. He’s doing the leg press machine. He’s got all these weights on there. He’s sweating profusely. I’ve got a camera crew because I want to capture this, because I want to show people this static contraction. So he finishes. He’s in the middle of a set. He finishes one of the sets, and this woman says, “Excuse me, sir. While you’re resting, can I jump in and just do a quick set?” He’s looking at her. He sees the camera. He thinks he’s being punked, and she goes, “Could you guys add 150 pounds?” I swear to God. She didn’t bring it all the way here to her legs. She was out here, and she held it and it fires off all those muscles.

Tony Robbins:
So I did that for several years. I’ve built 24 pounds more muscle in my body. I thought I was so great, but I got to 575 on the weights. I’ve got people trying to hold it, and then one arm was a little stronger than the other and I tore that, so I was in so much pain, I stopped doing it. I said, someday, somebody’s going to build something, but I thought it would be compressed air, so you wouldn’t have something that could kill you, but [crosstalk 00:52:25]. But now, there’s a company, and it’s called OsteoStrong. I invested with them because I was blown away. They took this technique, and muscle develop and is limited by the strength of your bones. Most people will know that.

Tony Robbins:
Most women know that osteoporosis is a real problem past 50, and most of the drugs fossilize the bones, this is the first technique. You’ve got to get three and a half times your body weight. Most people could never dream of doing that, but with this device, you can build to that point. My wife couldn’t do 120 pounds, and she’s done 350, to give you an idea, and it doesn’t your muscles bulky. It makes them long and sleek and strong and it’s four exercises with these machines. It takes 10 minutes. You can do it with your clothes on, and it works every muscle in your body. There are people that don’t want to work out, so now, there’s VR workouts, I’m sure you’ve seen, that are unbelievable. They’re so much fun and you don’t even realize you’re working out.

Tony Robbins:
So part of it is just consistency. Part of it is getting the right stimulus and the amount of rest still, because what happens is, if you overdo this, if you try and do it a week from now and you don’t improve, they say take 10 days off, and sure enough, come back in 10 days and you improve again. So there’s great breakthroughs in exercise, so it doesn’t have to just be doing the same crap over and over again and being bored silly.

Dr. Mark Hyman:
It’s true.

Tony Robbins:
You can really see it, and by the way, I’m sure you know, that lack of muscle, of the breakdown of the muscle, now it’s being seen by a lot of people in medicine as important as blood pressure.

Dr. Mark Hyman:
Absolutely.

Tony Robbins:
Because when people age, that’s what starts to break down. That’s why they end up in hospital. Now, the whole thing starts to break down.

Dr. Mark Hyman:
No, sarcopenia is the biggest driver of all the metabolic changes, low hormones, inflammation, blood sugar issues, all that stuff, and, Tony, I read in the book that you love that machine so much, you got one for your house, so I’m coming to Florida in April. I’m going to come over. I want to try it.

Tony Robbins:
Come over. I’ll have you check it out. It’s pretty awesome. It’s four machines, but come on over. We’ll do it.

Dr. Mark Hyman:
Okay. So Peter, tell us more about some of the basic foundational things, besides a diet, exercise, sleep.

Peter Diamandis:
We talked about keeping hydrated. We talked about food, minimizing sugar, whole plant diets, the work that this guy Dr. Mark Hyman speaks about and writes about so proficiently.

Dr. Mark Hyman:
That quack? That quack? I wouldn’t listen to him.

Peter Diamandis:
On the exercise front, it doesn’t have to be heavyweights. It’s just stressing the muscles. Muscle is a direct correlation between muscle mass and longevity. Most people die because they have a fall and break a hip or break a pelvis and end up in the hospital, and it’s a spiral from there. One of the things that I do, and I commend everybody, is I take as many of my meetings walking as I can. I will try and get 10 to 20,000 steps a day, because I’ll do my Zooms. They work on my phone. I wasn’t going to do this one walking, or I have a walking treadmill and I take my meetings there, and it’s getting as much as I can, so I feel good about it.

Dr. Mark Hyman:
Yeah, you dragged me out at 5:00 in the morning for a walk in the Santa Monica Pier one day.

Peter Diamandis:
I did. I did. I take as many meetings walking on the [inaudible 00:55:24]. I live in Santa Monica, so you might as well enjoy doing that, right? You have an excuse if you’re in the middle of Buffalo. That exercise mindset is so important. I cannot express enough, right? You all know those studies of a man and a woman who are deeply in love and the wife dies, then the husband goes a few weeks later or vice versa. You can will yourself to death and you can will yourself to life. You need to make sure that your vision of your future is bigger than the vision of your past. You’re excited to be alive. This is the most extraordinary time ever, and so what would it be like? What would you do with an extra 30 years of healthy life?

Peter Diamandis:
Now, most people get sad and they want to retire and they want to slow down. Why? Because they’re in pain. They’re not enjoying. They’re exhausted. They don’t have the energy. They’re in pain when they move. So what if you didn’t have that pain? What if you had the energy? This is the vision of healthy longevity we’re talking about, where you have the aesthetics, you look good, the cognition, you’re thinking clearly, the mobility, you’re moving well, and then it’s like, yeah, I’m in. Put me in for the next round, coach.

Tony Robbins:
Most people really don’t understand the power of their mind. We talk about placebos in that next to last chapter, which I told you, you’ve got to read that, because you can do all the health things, then you can mess yourself up with your mind. Placebos started in World War II. Most people don’t know that. They were discovered because they ran out of morphine. It was actually not the doctor. It was a nurse, and these people are going to go into shock, they’re in massive pain, and she hands him a saline solution that says here’s some morphine, because he was freaking out, so he injected him, and of course, he had total certainty it was going to work. He assured them, “Your pain will be gone in a few seconds. You’re going to be fine.” Not one person went into shock. Most of them, their pain disappeared, and they were given nothing but saline, but with total certainty.

Tony Robbins:
So he came back to Harvard after the war and he started what we now look as standard operational practice, which is comparing a drug to a placebo. Almost nobody talks about it, but lots of placebos outdo the drugs, but you don’t make billions of dollars telling people about a placebo. Here’s what’s really interesting. The bigger the intervention on the placebo, the more the brain seems convinced the greater the result, so if I give you a small pill versus a big pill versus an injection is more powerful, the most powerful is a fake surgery. The VA did a study on arthroscopic surgery. They took a third of the people and did a fake surgery. They just cut open the skin, sewed them right back up and did nothing, the nurses didn’t know, and then they followed up a year later, and the stats are in the book. It’s mind boggling.

Tony Robbins:
But the people, a year later, who had the surgery still have problems, still have pains. The ones without it, the majority had no pain, talked about how healed they were, because it was that powerful. It’s even more. Harvard has shown you don’t have to give something inert. You don’t have to give a placebo. They’ve given people a barbiturate and a red pill and said, “This is an amphetamine.” And the barbiturate’s going to-

Dr. Mark Hyman:
Make you sleep.

Tony Robbins:
It’s not a placebo. It’s going to make your body drop, and your body’s accelerated and vice versa. Dr. Langer there at Harvard’s a good friend of mine, who helped create mindfulness. She’s done these studies taking people in their 70s away to the cat skills, where she did this, I think it was two week long program, and they changed it, so everything there, the TVs, the radios had all the stuff from 35 years ago, told everybody, instruct them speak as the present moment as if it was 35 years ago, I think it was 10 days or two weeks, can’t remember, but what was insane was that their eyesight improved at the end of those two weeks. Their blood pressure improved. They looked better. It completely shifted, and I interviewed Norman Cousins when I was 24 years old. He came to one of my fire walks, because he was always interested in psychoneurology, and he saw this as fascinating.

Tony Robbins:
So We developed a great friendship and I interviewed him for my original… It wasn’t podcasts in those days. It was called power talk. It was this interview format I did. He told me a story. He said, “Tony.” He goes, “You need to understand that the mind will make you sick used improperly, and that it’s viral.” I said, “What do you mean?” He goes, “You know if somebody’s yawning and you find yourself yawning or they’re laughing and it’s not that funny, but they’re cracking up enough, you laugh?” He goes, “I’ll tell you an example.” He said, “I could give you a dozen of these.”

Tony Robbins:
He was there. He went to this college football game. I don’t think it was UCLA. It was a different one, and he said, “Somebody got really sick, projectile vomiting, and people saw it, and the doctor came who was on staff, and the doctor’s going through what he did that day, trying to figure out what was making him sick, and the only thing that was different than what the guy did daily was he had a vending machine Coke. So the doc decided, well, maybe there’s copper or something leaky in it, so he made an announcement across the loud speaker and told everybody avoid the Coke machine.” He said, “Tony, it was like a movie. People were projectile vomiting all over the place. They literally had 12 ambulances, 12, taking people back and forth to the hospital. An hour later, they did testing, found out it was all fine, and they told everybody and everybody healed.”

Tony Robbins:
And then, here’s the most important one. The CDC, we all know today that the biggest fear people have based on the world we’re in today we’re going to die of COVID, and outside aging, which is the number one factor, the real factors you control we all know is obesity. 80% of the people who die are obese. But here, I found this study with CDC, I put it in the book because nobody would believe it unless you read it. Everything’s documented.

Tony Robbins:
The number two killer on COVID, number two risk factor is going to make you die, anxiety and fear, because anxiety and fear suppresses the immune system. Anxiety and fear will make you not be able to catch your breath. Anxiety and fear. It’s just amazing, and yet, we look at our media, and they’re good people. They’re not trying to harm anybody, but they’re trying to meet their shareholders’ needs, which is get more eyeballs, and we all know fear sells. If it bleeds, it leads. So we’re living in a world where we need to take back control of that, and that’s really what the last two chapters of this book about, showing the tools, so you can shift all that in your life.

Dr. Mark Hyman:
It is still powerful. Yeah, I think Tony, you’re such a master of this, and in the book, you quoted Norman Cousins. He said, “Our bodies are apothecaries. We can bring our expectations into chemical reality.” And you say, “The quality of your life is the quality of your habitual emotions.” And, Peter, I want to come back to you to talk about some of the vitality pharmacy, some of the supplements, some of the advances in peptides, exosomes, all the stuff that people are doing, but before we do, I want to talk about the why. Because if you’re miserable inside, who the heck wants to live a long time, right? The quality of your life is the quality of your habitual emotions. What is your emotional home? And you talk about the three things that lead to emotional mastery, what we focus on, what does it mean, and what am I going to do? Can you unpack that in a couple of minutes for us? Because I think it so important.

Tony Robbins:
Sure, real easily. So I’ll tell you, I found it out when I was really young. The reason I feed 100 million meals a year is I was fed when I was 11 years old and we had no money and no food, and my mom and dad were fighting and my dad and mom were saying things. Once you say them, you can’t take them back. I’ve got a five year old younger brother and seven year old younger sister. I’m trying to make them not here, and there’s a knock at the door, and I go to the door and there’s this tall guy. I’m just a little kid, standing there, with two bags of groceries and an uncooked turkey on the ground, and he goes, “Is your father home?” And I was like, “Just one moment.”

Tony Robbins:
So I go get my dad, who’s screaming at my mom. She’s screaming at him, and I said, “The door’s for you.” He goes, “You answer it.” I said, “I did. It’s for you.” So I’m sitting there, a little boy, just so excited. My dad’s going to be so happy. He opens the door and he was not happy, and you’ll understand why this affects the mind, and he says to the guy, “We don’t accept charity.” And he goes to slam the door, but the man’s foot was there, he wasn’t trying to, and it just bounced off of his foot, and then my dad got a little madder, and he said, “Sir, sir, look, I’m just a delivery guy. Somebody wants you to have a great Thanksgiving. Everybody has tough times. This is for you.” My dad said, “We don’t take charity,” and started to push harder, and the guy leaned in, so now, it hit his foot and his shoulder, and I’ll remember and I’ll never forget. The guy saw me and there was a long pause, and he said, “Sir, please don’t make your family suffer because of your ego.”

Dr. Mark Hyman:
Wow.

Tony Robbins:
My dad’s veins on the side of his throat went crazy. I thought he was going to punch him in the face. There’s this long pause, and then he took the food. He didn’t say thank you and took the food and slammed the door. I didn’t figure it out then, but I was shocked. I was in so much pain, and then shortly after that, my father left our family, and so I was trying to uncap, figure out what this is, and I realized there’s three decisions we make every moment of our life, and if you take conscious control of these three decisions, you’ll have a different life. Most people do them unconsciously. 48% of what we do roughly is habit.

Tony Robbins:
So the first one is, what do you focus on? Because whatever you focus on, you feel, so if you focus on your kids, this is going to happen, it’s the worst thing. You’re going to feel sick to your stomach. It’s going to be real to you, because focus equals feeling, right? There’s three habits. Do you focus more on what you have or what’s missing? Most people focus more on what’s missing. Achievers, superstars focus more on what’s missing, so how do you sustain happiness? It’s never enough.

Dr. Mark Hyman:
Some of the most unhappy people I’ve met are billionaires.

Tony Robbins:
I interviewed 50 for my book, and without naming names, there were probably four, maybe five, that were really happy, at least in my presence, consistently around their family, which is crazy, but money didn’t do that to them. These habits did it to them, because it’s never enough. Second question, do you focus more on what you can or can’t control? Well, in COVID, most people focus on what they can’t control. There’s so much you can’t. So add what’s missing and what you can’t control, then our third one, do you focus on the past, the present or future? Lots of people, it’s the past or the future they’re worried about. So I ask people in my audiences, “How many of you know someone who takes antidepressants and is still depressed?” 90% of the room will raise their hand. How’s that possible? They’re taking a drug. Well, because the drug numbs them, but it doesn’t deal with the source. If you’re constantly focused on what’s missing and what you can’t control, you’re going to be pissed off or angry or sad or depressed.

Tony Robbins:
So, Stanford came to me, because you know how much… We’ve had the greatest drug overdoses in the history of the United States in the last year. We’ve had some of the greatest number of suicides, as you know, and so if you look at traditional, on the meta studies, these guys at Stanford came to me and said, “The meta studies show traditional therapy with drugs, for depression, and therapy, about 40% of the people improve. 60% don’t improve after a year’s worth of therapy, and of the 40% that improve, the average improvement is 50%, meaning they’re 50% less depressed. Some get totally well, some not at all. That’s the average.”

Tony Robbins:
And then there was a breakthrough that happened two years ago. John Hopkins decide to use psilocybin, a psychotropic drug, along with a month’s worth of therapy, and they got results that had never been seen in history. 53% of the people, 30 days later, did not have the symptoms of depression. It’s the greatest breakthrough we’ve seen. So they came to me and said, “We’ve talked to so many people. We’ve met people. We know people that have been through your programs or depressed. They’re no longer depressed, but that’s anecdotal. Would you mind if we did a scientific study?” So I went, “Sure.” So they took my Date With Destiny program, six days. They recruited clinically depressed people. They created a focus group or an alternative group to measure against. Most of the professors at Stanford, when they told [inaudible 01:06:25] and said, “Well, it’s just positive thinking,” and no clue what I really do. They said, “Okay, then what do you suggest?” They said, “Well, do gratitude journaling. That’s really a positive psychology. It works well.”

Tony Robbins:
30 days later, the people were still depressed. There was a slight improvement and depressed. They took the group. They went through six days of changing their perceptual filters, their belief structures, their values, for six days, no drugs. 100% of the people had no depression 30 days later. 19% had ideations of suicide, zero after 30 days. They did a study 11 months after the program. 70% reduction in negative emotions, 55% increase in positive emotions, no drugs.

Tony Robbins:
So there are things you can do within you that can change the quality of your life completely, but learning to control what you focus on, second decision, what does it mean? Is this the end or the beginning? If you’re at the end of a relationship, you’re going to behave very different than you think at the beginning. Is God punishing me? Is that why I have this problem? Is God challenging me? Is this a gift from God or am I just a lazy bastard? It’s not God’s fault. Is this person dissing me, coaching me or loving me? Because whatever you decide it means changes your emotion, and your emotion affects the last decision, what am I going to do? And if you’re pissed off, you’re going to do something very different than if you’re feeling grateful. So those three decisions are habits, and when you change them, you literally change the quality of your life.

Dr. Mark Hyman:
Honestly, Tony, the Life Force book is amazing for all the signs and longevity, but I found that section on mindset one of the most powerful parts of the whole book, and I think it’s important for people.

Tony Robbins:
So glad.

Dr. Mark Hyman:
Because we know, for example, that meaning and purpose extend life. If you have meaning and purpose, this is a recent gem article, and I think those are all really foundations to everything else we’re doing.

Peter Diamandis:
Optimists live longer.

Dr. Mark Hyman:
Yeah, I always say optimists live longer, even if they’re wrong.

Peter Diamandis:
It’s true. It’s absolutely true.

Dr. Mark Hyman:
I’m like that. It’s just a flesh wound. It’s fine. Nobody’s jumping on stage with a broken back. It’s just fine. It’s okay. Nevermind. So Peter, let’s dive into the vitality pharmacy part of the book, because I think that is so profound, and it’s stuff that’s safe usually, sometimes it’s stuff that’s a little on the edge. It’s available. It’s things people can do, and it’s, honestly, things that need more research for sure, but these are all things that I’m doing, that you both are doing, that we’re trying out and experimenting in ourselves as guinea pigs, and I think it’s such a powerful section of the book about the vitality pharmacy.

Peter Diamandis:
Yeah, so there’s a number of what we call nutraceuticals and supplements and medicines that are affecting the body, and the pathways in particular, the potential for this concept of age reversal. Tony mentioned it earlier, right? We have seven sirtuin genes that generate seven sirtuin enzymes, and these sirtuins are doing two things. They are going back and forth between keeping the epigenetic structure of your DNA as it should be, and then they’re going off to repair the DNA, then they’re going back and forth and the more repair you need, because you’re older and you have more mutations, the less they’re controlling your epigenetic programming, and it starts falling apart and accelerates falling apart, because what fuels these sirtuins is NAD, nicotinamide adenine dinucleotide. It’s this molecule that’s the energy currency, and so the question is, and as Tony said, we lose half of our NAD at least, so when you need it the most, because you’re repairing mutations and trying to get your epigenome back in shape, you’re down for the count.

Peter Diamandis:
So there are a number of NAD precursors, and there are two that are publicly discussed. One is NMN and the other is NR. NMN is something that you can find online. There are multiple providers. There are some crystallized. Tony mentioned MetroBiotech. I take about a gram of NMN a day, as does David Sinclair, as does Mark.

Dr. Mark Hyman:
I actually do shots of NAD.

Tony Robbins:
As do I.

Peter Diamandis:
Yeah, and then there’s nicotinamide riboside, NR, which is a precursor, just before NMN, and both of those are shown to increase intracellular, this is NMN, and you want your NAD inside your mitochondria, and so that’s one of them. Tony, do you want to talk about peptides a second?

Tony Robbins:
Sure, peptides are these proteins that they’ve been discovered a long time, but they were used by the Russians in the 80s for their athletes, and there’s a particular doctor there. He also worked with people in a submarine that were having radiation frequency, and so he made these discoveries, but we have a list of 14 of them, and some of them, for example, men can have a blue pill if they’re having difficulty for… But men, it’s only blood flow. For women, it’s desire. It’s a neurological trigger. So there’s one that actually is now shown to make a difference in women’s desire and men’s desire, as an example. There are some that are [crosstalk 01:11:25].

Dr. Mark Hyman:
Is that PT-141 or melanotan?

Tony Robbins:
Yes, 141, and then you-

Dr. Mark Hyman:
I use that. I started using it. I’m like, wow, okay then. I’m like, whoa, what is going on here? I’m 62.

Tony Robbins:
[crosstalk 01:11:38] look on his face. That looks says it all.

Dr. Mark Hyman:
I’m like, whoa.

Tony Robbins:
But most people would never believe that works, and there’s the ones for your gut. We could sit here and go for 45 minutes on them, but they’re listed in the book and you can see what it is, and here’s some of the options, but you need a person who’s qualified, obviously, to make sure this is what’s right for you, and there’s metformin. Maybe you want to touch base on that because I [crosstalk 01:12:00]?

Dr. Mark Hyman:
Well, I wanted to talk about the peptides for a minute, because I use peptides and I was very skeptical about them, both as a doctor and as a patient, for myself, but I started… I always try on myself, everything before I start doing anything else, and I started using it. I found a really profound difference. I recently tweaked my shoulder. I had a bicipital tendonitis from lifting or something, and I’m like, okay, I’m just going to shoot up some BPC 157 in there. And I just gave myself a little shot, like a diabetic needle, and 10 minutes later, I’m like, whoa, what the…? It’s just gone and I did another the next day and that was it. And I was like, this stuff really freaking works.

Peter Diamandis:
For everybody, a peptide is a sequence of amino acids. It’s the same components that make up our proteins, and these short chain peptides are signaling molecules, and they’re activating different repair mechanisms in the cells and they’re hitting the cell surfaces. There is a list of them. One of the things that we ended up doing in the book is identifying-

Dr. Mark Hyman:
And that’s in the book.

Peter Diamandis:
Yeah, identifying those that are… There’s a great chart. I’m just looking at it right over here. It’s identifying those that are approved by the FDA, those that are available, and then giving a chart of this one’s for weight loss, this one’s for increasing your growth hormone, this one’s for tendon or muscle repair, whatever the case might be.

Dr. Mark Hyman:
Immune system function.

Peter Diamandis:
Immune system function, absolutely. You mentioned metformin. Metformin, also known as Glucophage, is a drug that costs literally pennies per pill. It’s gone off its patent label. It’s been around for a while and it has two major objectives. Number one, it reduces your blood glucose level, so if you’re prediabetic, it was given for people who were prediabetic, but it seems to have a cancer protective feature. You’ll lose a couple of kilograms on the Metformin. It reduces the glycation, because glucose in your bloodstream, again, we talked about it being a poison. You get glycosylated cholesterol that can deposit on the heart. It causes neuro inflammation, and so, Metformin is a way of bringing your glucose levels down, and of course, cancer thrives on what? It thrives on glucose. It’s the only fuel that cancer uses, so if you can reduce your glucose levels, it’s like removing oxygen from the room. Cancer has a much harder time proliferating.

Tony Robbins:
By the way, if people are interested, they get the book, but if they go to lifeforce.com, if they do that and they say, “Well, God, I want to do diagnostics,” we have an app that you can download. So our company, which has multiple locations around the United States, but we can also direct it to you, like a CCTA test, your doctor can order it and we can set it up for you, so you don’t even have to necessarily come to our center, and then we have mylifeforce.com. If you go to Life Force, it’s there as well, which is a separate company that just does peptides and hormones for people, does the testing and delivering it for people as well. We try to provide people with simple solutions with professional doctors and telemedicine that’s available from wherever they are in the world.

Dr. Mark Hyman:
Yeah, it’s really a great resource.

Tony Robbins:
Yeah, the goal is, for me, the book doesn’t make a difference if it’s…
PART 3 OF 4 ENDS [01:15:04]

Dr. Mark Hyman:
Yeah. It’s really a great resource.

Peter Diamandis:
The book doesn’t make a difference if it’s just entertainment. If it doesn’t change the way you behave, the actions you take in your life, then please don’t pick it up. It’s meant to change the course of someone’s health span. The passion that Tony brings to impacting hundreds of millions of lives around the world, he brought to this book as well. And of course, it’s my passion as well of giving you, here are the assets, here’s the knowledge, here’s the on ramps, if you would, towards this incredible future we’ve got.

Tony Robbins:
I want to plant a seed about one more thing because some of your viewers or listeners may know somebody who has Parkinson’s, for example. And we have a chapter about this new technology called Insightec. It’s incisionless brain surgery, basically. If you’ve ever seen … I saw this woman who couldn’t walk across the room, on 15 different drugs, and wobbling. It’s pretty scary thing. It takes them about an hour to figure out the location, and then they do this ultrasound that zaps that part and it just stops. It is mind boggling.

Tony Robbins:
This woman just went on a 50-mile bike ride two years after her treatment, to give you an idea. Couldn’t walk across the room. And if you’ve ever seen somebody who’s gotten the ocular implants, when they can hear for the first time, crying, that’s the kind of reaction you get. If you know somebody you care about that’s got Parkinson’s, go look at Insightec. And what’s so cool about it is, it’s in a hundred hospitals now and around the world, but more importantly, it’s also linked to insurance. It’s something that somebody can really do, and it’s worth looking at to see whether it can make a difference because people in that situation are in really huge psychological and emotional pain, besides the physical challenge.

Dr. Mark Hyman:
Yeah. Tony and Peter, why the book is so great is it includes all the latest advances that are sci-fi, high tech, cool stuff that people are figuring out about how to fix people with real issues, but it also has really practical, foundational stuff for everybody to use. That’s why lifeforce.com and My Life Force are great resources because they help people navigate those territories of the vitality pharmacy. We just touched on a few, whether it’s Metformin or peptides or NMN or NAD, but there’s various supplements, broccoli sprouts. And you can’t do all of it, but I try to figure out, in my own life, how do I, in the context of my life, build the structures and the systems and the processes that make it easy for me to do the right thing every day.

Dr. Mark Hyman:
Today, I woke up. And I made sure I had a good sleep. I had my Eight Sleep mattress with a cool bed, my eye shades, my ear blocks. I’m a little goofy, but it’s not the sexiest thing in the world, but I got a good sleep, woke up. I did my journaling every morning to just get my mind straight. I played tennis. I took a hot steam and an ice bath. Did my peptides, had a great smoothie with all my … I call it my healthy aging longevity smoothie with all my good adaptogens and this and that. I did my NAD shot. It sounds like a lot and I’m a weirdo, but I like it. I also did five different DNA methylation tests to measure my biological age today because I want to see, one-

Peter Diamandis:
Please let me know what you find out. I really, really want to know.

Dr. Mark Hyman:
-is it legit, and two, is what I’m doing working, and three, what’s going to happen in six months from now as I do all these things because we are actually, Peter knows, launching the next prize for longevity. And it’s trying to figure out how do we measure and what are the metrics we can use to actually see if this stuff’s working or not because we can talk about all day long, but unless you can prove it’s working, like get your cholesterol down, that’s a metric, right, but there’s biological age clocks now. There are DNA methylation clocks and other clocks that people are looking at to measure the rate of aging. You mentioned yours was 50 something. I did my telomeres years ago. I was 57, I think, or eight at the time. I was 39.

Dr. Mark Hyman:
I’m curious to see what my DNA methylation clock is, but all these things are things for us to look at to try. And the foundational stuff is really key. And I think we can get off on tangents of look at all the cool gizmos and gadgets and diagnostics, and not everybody’s going to be able to get an MRI today, but the exponential technology that part of the book was so exciting, Peter, because we all, like you mentioned about the phone … I mean, I think my first calculator was over a hundred bucks and all it could do was add and subtract. And now, you’re talking about like this whole idea of exponential technology and people don’t get it. You say 30 exponential steps, regular steps, 30 steps, you go 30 meters. Thirty exponential steps, you go six times around the planet.

Peter Diamandis:
26 times. [crosstalk 01:19:27] 30 meters, yes.

Dr. Mark Hyman:
Oh, 26 times. All right. And then you get people, oh, you want a dollar a day for 30 days, or you want a penny a day that doubles every day. People, I want the dollar a day. That’s 30 bucks. At the end of the penny a day that you double every day, you get 10 million. People just have a hard time comprehending it.

Peter Diamandis:
Our brains are not wired for that. We’re linear thinkers in a scarcity minded world. And the technology that we’re developing, and remember I said earlier, we’re seeing billions, tens of billions of dollars, going into AI and massive computation. Quantum computing is coming. One of the things that quantum computing is going to do, I won’t go into the details here, but it’s going to allow us to simulate molecular chemistry and interactions. We’re going to be able to understand what drug is perfect for just you, not just for all humans, right? And we’ve seen AI, we’re seeing a company we talk about in Silicon medicine, that my venture fund is one of the many funds that backed it, that’s using AI to design new drugs that are a thousand times faster and cheaper to develop. It’s an extraordinary world. I do want to mention for science fiction comes science fact tech that’s in the book, I’m sorry, I have to do this.

Dr. Mark Hyman:
Go for it. Go for it. I was going to ask you about them actually. That’s where I was going. That’s where I was going.

Peter Diamandis:
Number one is regenerating organs, creating organs in you. We have a friend Martine Rothblatt, I’ve known her for 40 years, amazing, who saved her daughter’s life by finding the drug to solve her lung disease. But, she said, “Listen, there’s a hundred thousand people on the waiting lists for hearts, livers, kidneys, and lungs. We just don’t have of enough people dying in motorcycle accidents to provide them, nor enough organ donors.” I’m an organ donor. Should I pass, I want my organ to be gone to use.

Peter Diamandis:
But, at the end of the day, what she did was work with Craig Venter to engineer 10 genes in the pig genome to remove what are called endogenous retroviruses, and to change the surface proteins so that you were effectively humanizing the pig. It turns out that a pig has the same size heart, liver, lung, kidney, as a human does. If you could humanize that pig, when you sacrifice it, you’ve got literally a near infinite supply of organs as well as bacon. This is not theory. It was actually demonstrated a few months back using a pig-originated kidney transplanted into a human, right? It’s magical stuff. Then we talk about another brilliant individual, Dean-

Tony Robbins:
By the way, it was just done with a heart a few weeks ago. Martine was part of that because I reached out to her to [inaudible 01:22:25] because she said to us when we asked for timing, she says, “By time people are reading your book, I think it’ll be happening.” And that was a year ago. It sounded ridiculous at that stage, but it’s actually occurring, but what’s even more exciting is … Go ahead, Peter, show what’s being done. It’s amazing.

Peter Diamandis:
Yeah. Dean Kamen, who’s the creator of FIRST robotics and implantable insulin pumps. He’s got 1500 patents. He’s one of the most-

Dr. Mark Hyman:
He’s like the Edison or Tesla today, right? He’s like that.

Peter Diamandis:
He’s the Edison or Tesla today without question. He said is just an incredible soul. He was not in the bio area; he was building robotic arms and robotic leg replacements. At the end of the day, he ended up getting a grant from the US military, about 150 million dollars total. He built a consortium called the Advanced Regenerative Manufacturing Institute, A-R-M-I, ARMI. What they’ve done is they’ve built the machine that in one end of the machine, you put those induced pluripotent stem cells. You take a skin cell from yourself, you turn it into an earlier precursor stem cell that can then differentiate. You put it in the beginning of the machine. Over the course of a month and a half to three months, it differentiates into the tissues, and then it’s engineered and manufactured, so at the end of those three months, you’ve got a pediatric heart that has come out that is ready for transplantation. They’ve already bone ligament and bone segments for your knee repair, your ankle repair.

Dr. Mark Hyman:
The body shop.

Peter Diamandis:
Yeah. The next target … The military is doing it because they want to supply of organs for injured vets and so forth, but this is, I mean, between those two approaches, and there are a number of other ones as well, it’s like we have the ability to give you a replacement set of organs, which connects me to the next breakthrough, which is the work that Bob [inaudible 01:24:21], one of our partners in this book does. Bob discovered years ago that the placenta, that I think of as a 3D printer that manufactures the baby, is the origination of all of the stem cells that are used to differentiate and make the fetus.

Peter Diamandis:
Everybody, most everybody, has the placenta thrown away after the after birth. But, Bob said, “No, no, no, I’m going to save it. I’m going to extract from the placenta, the cells.” What it comes out of placenta, one is stem cells, a perfect age zero stem cell population that can be used and is going into research right now for regenerating muscle, being able to actually grow organs, being able to reduce inflammation, a whole slew of different benefits. Exosomes. Exosomes are the growth factors that come out of stem cells, and then natural killer cells and T-cells. And what Bob has done in his company-

Dr. Mark Hyman:
Those are part of your immune system.

Peter Diamandis:
Yeah. T-cells and natural killer cells. It turns out that there’s very few cases ever of a pregnant mother transferring cancer to the fetus. There’s no metastases to the fetus. It turns out that the natural killer cells in the placenta are extraordinary at identifying cancer cells and zapping them, and so what Bob realized was these natural killer cells from the placenta are supercharged and he has turned them into cells as a medicine and where he’ll provide someone with a variety of cancers, including glioblastoma, which is just an extraordinarily harsh and incurable cancer, and finding that these natural killer cells can actually eliminate the glioblastoma. It’s just an amazing world. I got one more, but let me take a breath and let-

Dr. Mark Hyman:
Well, I just want to point out something that speaks to what you’re both talking about, which is this radical paradigm shift in medicine and science, it’s unlike anything we’ve ever seen before. It’s not an incremental improvement in our approach. It’s a fundamental shift in our entire view. There’s some converging trends that make this possible, which are all coming together in this beautiful way, systems biology, network medicine, functional medicine, whatever you want to call it, which is really looking at the root causes and the biological networks. I mean, we have 37 billion billion chemical reactions every second in our body. It’s just stupid to think that a doctor could actually look at a lab test with 37 billion billion lab results on it, right?

Dr. Mark Hyman:
But, we now have that, then we have our ability to crunch those numbers, using big data capabilities, machine learning and artificial intelligence, and then the quantified self metrics, which are all the things that you’re talking about like the womb. I have my levels glucose monitor on here. I’m like I played tennis day, why did my tennis go up so high? I think I was in such a stressed state, my blood sugar went up. I’m learning so much about my own body. All that day is going to be put into a way for us to look at all these metrics. You mentioned gigabytes and gigabytes of data from the Fountain Life workup, but we’ve never had that before. We’ve never been able to see the correlations and the patterns through quantum computing, through artificial intelligence, networks, understanding our networks and biology.

Dr. Mark Hyman:
We’re literally going to be able to change how we think about health and disease in a way that gives us the answers to things we never even thought possible. And then we have all the technology advancements like nanotechnology and nano bots and little 3D printing of organs and augmented reality and gene sequencing and editing. I mean, this is next generation stuff.

Tony Robbins:
Staggering, isn’t it? Staggering.

Dr. Mark Hyman:
It’s staggering. And this is on top of the basic foundational lifestyle stuff, which we already know works so well, right? That works so well. This is like just boom. Okay. Wow. I’m so glad to be alive right now. I can’t even tell you.

Peter Diamandis:
100%

Dr. Mark Hyman:
I’m so glad to be on this journey with you guys because you’re all my peer group. You’re all like 60 something guys.

Peter Diamandis:
I’m younger by 18 months, and I’ll take it.

Tony Robbins:
Well, we’re grateful to have you, Mark.

Dr. Mark Hyman:
-Who love life and just want to keep contributing and giving and doing because, think about it, it’s not just a narcissistic pursuit to live longer so you can get more stuff and do more things. It’s about service and love and connection and community and making the world better. I mean, in the Jewish tradition, there’s a constant called “tikkun olam”, which means to repair the world, to heal the world, to bring justice and goodness wherever we go. And what a wonderful gift to be able to get people who’ve done a lot of the hard work in their life to get to that point and now have the energy, vitality, and the ability to do this. It’s so amazing.

Peter Diamandis:
Yeah. It truly is. An interesting fact that, or piece of research, came about six months ago out of Oxford, London School of Business, and Harvard, that if you can increase the average lifespan globally by just one year, it’s worth 38 trillion dollars to global economy, right? And this great resignation where we’re concerned about where are we going to get the workforce from and so forth, ideally, it’s people want to stay in the game longer. At the top of your game, when you’re 65, 70, 75, I can’t imagine retiring ever, but. And by the way, there’s a correlation between retirement and death that is not fun for men to look at. Not initially for women as much, but for men, it’s like five years after retired that you’re no longer … you give a signal to the universe, it’s time for me to give my parts back.

Dr. Mark Hyman:
Yeah. We’re not talking about all these decrepit, old people who are nursing homes, living longer. We’re talking about people who are engaged and alive. I saw that study. That was in Nature Aging, I mean 38 trillion for one year. For 10 years, it was 367 trillion. You contrast that to the four trillion we spend today on chronic disease in our economy. One in five of our dollars of our economy is spent on dealing with all the problems that are going to be solved if we can figure this out. Imagine. We could end poverty. We could end hunger. We could give everybody free education, free healthcare. I mean, that’s an enormous amount of money.

Tony Robbins:
You think about the wisdom you accumulate over the years, if you’ve really grown. You have so much to give if you are healthy, if your brain is healthy, and so forth. There’s all these studies that show that when you look at where healthcare expense goes, people who make it to centenarians or close to it, in their nineties, they are very sick for a short time and die rapidly. It’s the people that get sick in their sixties, fifties, and seventies that have these long periods of time of suffering and huge expense to society. Our capacity to expand health span, not just lifespan, is I think the single most valuable thing that we have in front of us right now that can change society for the better.

Dr. Mark Hyman:
Yeah. That’s such an important point, Tony, because James Freeze did this work. His first paper was in England Journal of Medicine, 1980. And basically 16 years of the average life is spent decrepitude, right, which is a lot of years. He talks about how people who exercise, keep to their ideal weight and didn’t smoke … Those are just three simple things. We’re not talking about all these other cool stuff we’re talking about. They act actually compressed their morbidity into the very little bit of the end of their life. It means their health span equaled their lifespan. They didn’t have those 16 years of decrepitude. And they were able to live long, healthy, vibrant lives and then just die. My dream is when I’m 120 or maybe 180, go to the cabin with my lover, go for a beautiful hike, swim in the lake, have my favorite meal, a glass of wine, make love and go to sleep, and that’s it. That’s my goal.

Peter Diamandis:
Peace out.

Tony Robbins:
That’s a compelling vision.

Dr. Mark Hyman:
Well, you guys, this has been such a great conversation. Are there any final words that you have?

Peter Diamandis:
We have, for the first time ever in human history, a chance to look at aging as a disease. We also have a chance to cure and get rid of probably almost all genetic diseases and probably to begin curing, over the next decade or two, most chronic disease. We’re heading towards a world in which AI, biotechnology, is literally demonetizing and democratizing access to healthcare. If you think about it, my opinion, Mark, is it’s going to become malpractice to diagnose a patient without AI in the loop. There’s no way that you can-

Dr. Mark Hyman:
Yeah. 100% right.

Peter Diamandis:
Probably within the next five years. If you think about Google provides equal, exact capabilities to the poorest child and the wealthiest child, right? It’s not just a little bit better for the wealthy. It’s identical. We’re going to see AI delivering the best healthcare to the poorest child and the wealthiest child, and education to the poorest and the wealthiest as well. There’s an incredible future that humanity has. We’ve got work, but I’ve never been more excited. Part of the longevity mindset we want you to have from reading this book is there is tremendous hope, and it’s worth staying in the game. It’s worth exercising. It’s worth getting sleep. It’s doing those things a little bit every day to give you a chance to intercept the next and the next breakthroughs coming our way.

Dr. Mark Hyman:
I mean, in the time of this history where things often feel a little bit frustrating, and divisiveness in our society, and some of the challenges we’re facing, I mean, this is such a hopeful message. I hope we can take it to heart and rethink the way we look at our lives and disease and health and reimagine the future for ourselves. Tony, what do you think?

Tony Robbins:
I think that the most important thing, everything we’ve talked about is priceless, but what’s, I think, equally or maybe even more priceless is having a longer life, you’re never going to have it unless you have a meaningful life. And a meaningful life is not just about yourself. If you look at people who have an extraordinary quality of life, an extraordinary kind of energy, it’s because it’s called forth by something. There’s two types of motivations in this life: there’s push, trying to make something happen, and there’s pull, where you’re called to something. I think when people find something they care about more than themselves, they truly care about, and I don’t mean care about the surface, I don’t mean virtual signaling, I mean, where you know it’s your family or it’s making a difference in disease or it’s whatever that is you really than yourself, that’s what makes us want to use all our resources and stick around for a period of time.

Tony Robbins:
Because living long is not a scarcity, which sounds like we’re going to get to at some stage. The new question is what are you going to do with it? I think the time to answer that question is right now because if you answer it now, you’re going to have a reason to want to stick around. You’re going to have a reason to do these things. If you don’t have that, you can forget it. I’ve got five kids and five grandkids. And I have 10-month old, as of yesterday, daughter and a 48-year-old daughter, right, so it’s like I’ve got to apply all this stuff so I can stick around, right, because I want to be here. I have my mission. I have my family. And you’ve got to figure out what it, that you value more than yourself. If you can find that touchstone, and everyone can, get around where it’s better, get around people who are passionate about things, then something’s going to touch you. Then you’re going to find the drive to take these tools, little ones, big ones, and use them.

Tony Robbins:
What we’ve tried to provide here is a guidebook where you can do some really simple things and change it, or when you need it, there’s some great tools for you or a family member, or if you’re one of those people, it’s about peak performance and regeneration, holy cow, there’s some tools here that will change your life, but you got to have a reason. The reason is not just you because it’s easy to get comfortable with yourself. What’s really interesting is can you be called to something greater that makes your life meaningful because in the end, success is getting what you want. Meaning is feeling like you’ve lived a life you’re made for. I think finding that is one of the highest and most important things for human being to do because all the rest of this is just table dressing without meaning. We all three have that.

Tony Robbins:
That’s why we’re so driven. That’s why we want to help. That’s why we work hard. None of us have to work, but we’re doing more today than we did in our twenties and our thirties and forties. We’re making demands, but we’re enjoying life to a different level because it isn’t just about us. I really call to people to think about what will ignite you. And with the last couple chapters about the book are a good trigger for that as well, but you can start thinking about it right now because once that’s solid, you’re going to figure out how to maximize everything, including your health and your vitality in the extreme.

Dr. Mark Hyman:
Well, both of you, I just have to give you kudos because it is no small task to do what you did, to find the world’s expert, to synthesize all the data, to put it in a story that people can read. I mean, I’ve read a lot of books on science. This is, I think, the only one that made me cry many times. It was beautiful. With all the stories in it-

Tony Robbins:
That was my goal, Mark. That was our goal.

Dr. Mark Hyman:
To make me cry?

Tony Robbins:
No, but to try to inspire you. Some of the tears are because you’re inspired by the people that gave so much, right?

Dr. Mark Hyman:
Of course. It’s so beautiful. And I think it’s such a gift. Everybody really should get a copy of Life Force. It’s out now anywhere you get your books. Go to lifeforce.com, learn about what they’re talking about. This is going to change your life truly. And I just want to give you such, such honors for the work that you both do in the world, making this place better than when you came in and leaving it in a much better place. Thank you.

Peter Diamandis:
Thank you, Mark. Thank you so much.

Tony Robbins:
Thanks for all the work you’re doing. Your along the path with us here, and we’re grateful to have us all together on this path, trying to find the best answers for everybody, including-

Peter Diamandis:
Exciting for our decades, many decades ahead.

Dr. Mark Hyman:
Yeah. We’re just getting started, right?

Peter Diamandis:
Just getting started.

Dr. Mark Hyman:
I want you guys both to be at my 120th birthday, for sure.

Tony Robbins:
Really. We’ve got to be there because we’re almost the same age.

Dr. Mark Hyman:
I know. We should have a joint birthday. Yeah. For those of you listening, if you know anybody who’s growing older, which is probably about seven billion people, I encourage you to share this podcast with them. I think it will help. Leave comments about what you’ve learned about how to improve your vitality and energy, and what you’ve learned about longevity. Subscribe wherever you get your podcasts. We’ll see you next time on the Doctor’s Farmacy.

Closing:
Hi, everyone. I hope you enjoyed this week’s episode. Just a reminder that this podcast is for educational purposes only. This podcast is not a substitute for professional care by a doctor or other qualified medical professional. This podcast is provided on the understanding that it does not constitute medical or other professional advice or services. If you’re looking for help in your journey, seek out a qualified medical practitioner. If you’re looking for a functional medicine practitioner, you can visit ifm.org and search their “find a practitioner” database. It’s important that you have someone in your corner who’s trained, who’s a licensed healthcare practitioner and can help you make changes, especially when it comes to your health.

If you are looking for personalized medical support, we highly recommend contacting Dr. Hyman’s UltraWellness Center in Lenox, Massachusetts today.

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