Content Library Articles Longevity Journal

The Most Overlooked Cause of Aging and Disease: Your Microbiome

March 1, 2024

Of all the body’s systems, the gut ecosystem might be the most complex—and, perhaps, the most critical to longevity and disease prevention.

Though medicine has long dismissed the gut as an isolated system of tubing with little import outside of acid reflux and irritable bowel issues, we now know that imbalances in the gut are inextricably linked to inflammation, accelerated aging, and nearly all chronic disease including cancer, diabetes, heart disease, and dementia.

In fact, scientists have effectively been able to reverse aging and disease in aged mice simply by modifying their gut microbiome with fecal transplants from young, healthy mice—and vice versa, accelerating aging and disease in young mice by disrupting their microbiome with transplants from older mice.

Why did this work? Because the gut, more than “just a tube,” is a microbiome that’s home to some five thousand species of bacteria and as many bacterial cells (roughly 30 trillion) as we have human cells.

When in balance (symbiosis), these bacteria keep the body in health. Yet when out of balance (dysbiosis), bad bacteria can grow like weeds, outnumbering good bacteria and creating a toxic environment that weakens the gut barrier, allowing waste products like undigested food particles and bacterial toxins to leak into the bloodstream—driving chronic inflammation and increasing the risk of virtually everything from obesity and auto-immune disease to heart disease, dementia, diabetes, and cancer (the “four horsemen” of the aging apocalypse).

The beneficial gut microbe Akkermansia muciniphila, for example, stimulates the secretion of glucagon-like peptide-1 (GLP-1), which plays a crucial role in regulating glucose levels and metabolism, and numerous studies have linked low levels of the microbe to diabetes , insulin resistance, obesity, and metabolic syndrome. Similarly, gut microorganisms can synthesize metabolites that trigger inflammation and cardiometabolic diseases—and levels of certain gut bacteria, such as Enterobacteriaceae and Streptococcus, are strongly linked to atherosclerosis. More broadly, systemic inflammation from dysbiosis can facilitate the development and progression of cancer as well as neurological disorders through the gut-brain axis.

It's no wonder Americans are facing unprecedented and exponential illness, given that 60 percent of our calories come from ultra-processed foods that fuel these “bad bugs” and destroy the microbiome.

Because diversity in the gut microbiome also tends to decrease with aging, creating an opportunistic environment for bad bugs to thrive, aging can often accelerate gut issues.

Fortunately, there are simple strategies we can take to restore the gut once we understand how it functions.

Gut bacteria are picky eaters. But we know what they like and don’t like. Bad bacteria thrive on starches, sugars, and ultra-processed foods. Good bacteria feed on prebiotic fiber (avocados, artichokes, asparagus, berries, peas, chia seeds, and pistachios), probiotics (fermented foods like sauerkraut, pickles, tempeh, miso, natto, and kimchi), and polyphenols in colorful plants (olive oil, turmeric, pomegranate, cranberries, green tea).

So, significantly reducing sugars and starches, especially as part of processed foods, and upping your intake of prebiotic, probiotic, and polyphenol-rich foods can help bring your gut into balance.

Because you want to foster a diversity of beneficial gut bacteria, you also want to aim for diversity in your diet, e.g., eating a variety of polyphenols from red, yellow, green, purple, and orange vegetables.

Numerous studies have shown that supplementing with colostrum has a remarkable ability to strengthen and repair the gut wall and prevent intestinal permeability, as colostrum is rich in growth factors and bioactive compounds that help repair the intestinal lining; antibodies that protect the gut from pathogens; anti-inflammatory components that reduce inflammation; and milk oligosaccharides that act as prebiotics to support a healthy microbiome.

Even if you’re eating all the right things—and eliminating the wrong things—you may need some outside assistance maintaining plentiful and diverse gut bacteria and repairing the gut lining.

Probiotics help populate your gut with beneficial strains of bacteria and are critical to protecting and rebuilding the gut. They also modulate intestinal function, improve immune function, are anti-inflammatory, and help us break down food into absorbable nutrients. Prebiotics, meanwhile, are a form of soluble fiber that feed good bacteria in the gut. Some of my favorite brands for revitalizing the gut and maintaining gut health are Microbiome Rejuvenate, BiotaGen Capsules, and BiotaGen Powder.

Ironically, many of the drugs commonly prescribed to alleviate gut problems also cause gut problems, particularly acid-blocking medications such as Prilosec, Prevacid, and Nexium, which prevent the absorption of essential nutrients and can lead to dysbiosis in the gut.

Other medications that can damage the gut include antibiotics, steroids, birth control, and anti-inflammatories like ibuprofen and aspirin. (For inflammation and pain relief, consider curcumin, an anti-inflammatory compound found in turmeric that’s proven comparable in studies to NSAIDs like ibuprofen—and, as a bonus, also happens to support gut health.)

Does this mean you should hit the gluten-free aisle? Not exactly. Many industrial additives, thickeners, emulsifiers, and gums that are added to gluten-free foods (such as microbial transglutaminase and carrageenan) can also cause gut damage and leaky gut. So be weary of ingredients you don’t recognize or can’t pronounce and aim to get as much of your nutrients as possible from whole food sources.

If you want to live a long and healthy life, it is essential to tend to your inner garden: the microbiome.

References

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