IBS: It’s Not In Your Head—Advances In Diagnosing And Treating, Bloating And Tummy Troubles

Episode 786 1h 2m


An estimated 70 million people in the United States are affected by IBS, SIBO, or another disease linked to digestive health, and 74% of Americans say they live with symptoms of digestive discomfort.

Today on The Doctor’s Farmacy, I’m excited to talk to Dr. Mark Pimentel about getting to the root cause of IBS and SIBO, how to properly diagnose and treat it, and strategies to improve your overall gut health. We kick off our conversation by talking about the difference between IBS and SIBO and the different subtypes associated with each.

Dr. Pimentel explains that while SIBO and IBS are separate medical conditions, they commonly coexist, can be connected, and share similar symptoms. We now know that food poisoning can trigger and lead to a cascade of events in the gut that result in IBS. Dr. Pimentel explains how toxins produced by bacteria, such as salmonella, can severely harm the digestive system by damaging nerves critical to healthy gut function, and how post-infectious IBS can also lead to autoimmunity.

We also discuss other causes of IBS beyond food poisoning. Dr. Pimentel explains that 60% of IBS is SIBO. The other 40% can be caused by Ehlers-Danlos syndrome, POTS, celiac disease, food sensitivities, histamine sensitivities, or fungal overgrowth. Diet is a critical aspect of IBS and SIBO management. We discuss the low-fermentation eating plan that Dr. Pimentel developed and why it could be a better option than a low-FODMAP or elemental diet, which are commonly used for IBS and SIBO. There are three different types of bacteria when it comes to SIBO—methane-producing, hydrogen-producing, and sulfide-producing. Dr. Pimentel explains how he differentiates between the three and how he determines what the right treatment is for a patient in terms of diet, lifestyle, supplements, and medication. We also talk about strategies to decrease the chances of IBS and bacterial overgrowth recurrence, whether probiotics are helpful or harmful, and simple testing options for both IBS and SIBO.


This episode is brought to you by Rupa Health, BiOptimizers, Sunlighten, and ARMRA. The Doctor’s Farmacy podcast works with a select group of sponsors to allow for ongoing production and allow it to be zero-cost to anyone who wishes to listen to and watch the podcast.

Topics Covered

  • What are IBS and SIBO and how are they different?


  • Food poisoning as the root cause of gut symptoms


  • Fungal overgrowth, or SIFO


  • Testing and treating various types of IBS


  • Low-fermentation eating


  • Managing recurring IBS


  • When probiotics worsen IBS


  • Intestinal methane overgrowth


  • The gut-brain connection


  • PCOS and gut issues


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Resources Mentioned

Host & Guests


Automatically generated. Please forgive any typos or errors in the following transcript. It was generated by a third party and has not been subsequently reviewed by our team.

Coming up on this episode of the Doctor's Pharmacy,

Dr. Mark Pimentel:
We want our I B S patients to feel as normal and as socially non-isolated as possible.

Dr. Mark Hyman:
Welcome to Doctor's Pharmacy. I'm Dr. Mark Hyman. That's pharmacy with an f, a place for conversations that matter. And if you have tummy troubles, if you have irritable bowel, if you get bloated, if you feel like you get a food baby after eating well, you're going to love this podcast. It's with the man who has basically changed the map of how we understand how to deal with what's called irritable bowel syndrome. And when I went to medical school, it was this thing that we called Super Tentorial,..

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Ep. 786 - IBS: It’s Not In Your Head—Advances In Diagnosing And Treating, Bloating And Tummy Troubles