The Science Of Your Gut Microbiome: How Healing Your Gut Can Improve Your Physical and Mental Health

Episode 838 1h 29m


While science and medicine have certainly come a long way in the last 2,400 years, emerging science has proven Hippocrates was right all those years ago—all disease begins in the gut. This means our gut microbiome, including gut bacteria and the integrity of our gut lining, strongly affects our overall health.

On today’s episode of The Doctor’s Farmacy, I’m excited to talk to Dr. Steven Gundry about gut diversity and how a diverse gut biome is directly linked to health and longevity. Dr. Steven Gundry is one of the world’s top cardiothoracic surgeons and a pioneer in nutrition. He hosts a top-rated health show, The Dr. Gundry Podcast, is the founder and Director of The International Heart and Lung Institute Center for Restorative Medicine, and is the founder of Gundry MD, a line of wellness products and supplements. There has been an explosion of research and understanding of the important role of our gut microbiome. Yet, despite regulating so many bodily functions and being critical to our overall and long-term health, conventional medicine has not integrated this knowledge into its teaching or practice. Dr. Gundry and I begin our discussion by talking about how we each came to learn about the significance of the gut microbiome throughout our medical careers.

When our microbiome is out of balance, it affects our immune system, hormone levels, mental health, longevity, and our risk for developing autoimmune, heart, and neurodegenerative diseases, as well as arthritis, diabetes, and cancer. Dr. Gundry walks us through the hallmarks of a healthy microbiome and explains the concept of mitochondrial uncoupling and how that helps us maintain a healthy, impenetrable gut wall. He also shares the keys to a healthy microbiome, and we go in-depth on the role that polyphenols—those colorful compounds found in plant foods—play in feeding our gut bacteria. We’re just at the beginning when it comes to understanding every interaction and reaction that takes place in the gut microbiome.

You’ve likely heard about prebiotics and probiotics. Now, Dr. Gundry explains the importance of postbiotics and how they are made in our gut. We also dive deep into the latest understanding of how compounds like urolithin A and resveratrol regulate so many areas of health, and Dr. Gundry explores the relationship between the gut microbiome, depression, and mood disorders, as well as how the microbiome relates to the effectiveness of immunotherapy drugs in cancer treatment. And finally, we talk about the prevalence of leaky gut and the top foods Dr. Gundry recommends avoiding to create a healthy microbiome. I hope you’ll tune in.


This episode is brought to you by Rupa Health, MitoPure, Beekeeper's Naturals, and . The Doctor’s Farmacy podcast works with a select group of sponsors to allow for ongoing production and allow it to be zero-cost to anyone who wishes to listen to and watch the podcast.

Topics Covered

  • How Dr. Gundry and I discovered the significance of the gut microbiome


  • Hallmarks of a healthy microbiome


  • Feeding the microbiome


  • Maintaining a healthy, impenetrable gut wall through mitochondrial uncoupling


  • The role of polyphenols in the gut microbiome


  • Research on the microbiomes of centenarians and their ability to produce Urolithin A


  • The mood, brain, gut connection


  • Cancer and the gut microbiome


  • Dr. Gundry’s tips for gut health


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Resources Mentioned

Host & Guests


Automatically generated. Please forgive any typos or errors in the following transcript. It was generated by a third party and has not been subsequently reviewed by our team.

Dr. Mark Hyman: Coming up on this week's episode of the Doctor's Farmacy,

Dr. Steven Gundry: Depressed individuals have a depressive microbiome and you can constitute these particular abnormal species.

Dr. Mark Hyman: Welcome to the Doctor's Farmacy. I'm Dr. Mark Hyman, and this is a place for conversations that matter. And if you ever wondered how the microbiome plays a role in our health across all manner of diseases and health conditions, you're going to love this podcast because today I'm bringing you a fascinating conversation with one of the leading thinkers in health and wellness, Dr. Steven Gundry about one of my favorite topics, the gut microbiome. Steven Gundry is one of the world's top cardiothoracic surgeons and a pioneer nutrition. He..

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Ep. 838 - The Science Of Your Gut Microbiome: How Healing Your Gut Can Improve Your Physical and Mental Health