Is Histamine Intolerance The Cause Of Your Mysterious Symptoms?

Episode 41 44m


Most people are familiar with certain histamine conditions, such as the development of a welt from a bee sting or hives from a peanut allergy. However, symptoms ranging from brain fog to digestive problems, menstrual cycle problems, nausea, vomiting, edema, palpitations, and anxiety can all also result from issues of histamine intolerance. Unfortunately, this issue commonly goes undiagnosed, often resulting in years of ongoing frustration and suffering among individuals struggling to find the cause of their mysterious symptoms. In this episode, Dr. Hyman sits down with Dr. Todd LePine to talk about how they work with patients to get to the root cause of histamine intolerance. They discuss the rising prevalence of mast cell activation syndrome (MCAS), how gut health influences histamine, and much more. Dr. LePine graduated from Dartmouth Medical School and is Board Certified in Internal Medicine, specializing in Integrative Functional Medicine. He is an Institute for Functional Medicine Certified Practitioner. Prior to joining The UltraWellness Center, he worked as a physician at Canyon Ranch in Lenox, MA, for 10 years. Dr. LePine’s focus at The UltraWellness Center is to help his patients achieve optimal health and vitality by restoring the natural balance to both the mind and the body. His areas of interest include optimal aging, bio-detoxification, functional gastrointestinal health, systemic inflammation, autoimmune disorders and the neurobiology of mood and cognitive disorders. Dr. LePine teaches around the world, and has given lectures to doctors and patients at American College for Advancement in Medicine (ACAM), Age Management Medicine Group (AMMG), the University of Miami Integrative Medicine Conference, The Kripalu Center in Lenox, MA, and is on the faculty for American Academy of Anti-Aging Medicine (A4M). Dr. LePine is the head of the Scientific Advisory Board for Designs for Health and a consultant for Diagnostic Solutions Laboratory. He enjoys skiing, kayaking, hiking, camping and golfing in the beautiful Berkshires, and is a fitness enthusiast. This episode is sponsored by Athletic Greens and Dr. Hyman’s Sleep Master Class. Athletic Greens is offering Doctor’s Farmacy listeners a full year supply of their Vitamin D3/K2 Liquid Formula free with your first purchase, plus 5 free travel packs. Just go to to take advantage of this great offer. In this modern world we place too much value on staying busy and deprioritizing sleep, which is why Dr. Hyman created his first ever Master Class. It guides you through the most important steps to getting better sleep, starting today. Get free access to Dr. Hyman’s Sleep Master Class at In this episode, Dr. Hyman and Dr. LePine discuss:
  • Symptoms of histamine intolerance
  • The rising prevalence of Mast Cell Activation Syndrome (MCAS), and the effect of EMFs on mast cells
  • Histamine producing foods, and the connection between histamine intolerance and leaky gut
  • Testing and diagnosis of histamine intolerance
  • Pharmaceutical drugs that drive histamine intolerance
  • Nutrients that support histamine balance
  • Patient cases

Resources Mentioned

Host & Guests


Automatically generated. Please forgive any typos or errors in the following transcript. It was generated by a third party and has not been subsequently reviewed by our team.

Dr. Todd LePine: It's a spectrum illness. You can have mild, moderate, and severe forms of it. There's a whole variety of different things that are involved. You have to treat each person individually looking at their unique situation, their history, their genetics, their gut microbiome. Dr. Mark Hyman: Welcome to Doctor's Farmacy. I'm Dr. Mark Hyman. That's Farmacy with an F, F-A-R-M-A-C-Y place for conversations that matter. If you feel like crap, you may be suffering from a rare condition, which may not be so rare, called histamine intolerance which we'll get into. You're aware of antihistamines which is when you have an allergy, but a lot of people make too much histamine which is what causes all the allergies. They just feel like crap. They have swelling and..

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Ep. 41 - Is Histamine Intolerance The Cause Of Your Mysterious Symptoms?